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Pyrroloquinoline quinone (PQQ): From Stardust to Mitochondria

by Matt Jarosy – December 29, 2022

AntioxidantEnergyMetabolismMitochondriaRedox
PQQ, COQ10 and mitochondria

We recently launched our mitochondrial support supplement, Metabolic Flow, which contains a unique compound called Pyrroloquinoline Quinone (PQQ). In this article, we’ll explore what PQQ is, how it works, and why it’s such an intriguing nutrient for cellular energy, brain function and overall vitality.

What is PQQ?

PQQ is a naturally occurring molecule found in plants, bacteria and some animal tissues. Structurally similar to a vitamin, it functions as a redox cofactor – meaning it assists in chemical reactions involving electron transfer. These reactions are essential for generating energy and protecting cells from oxidative damage. Interestingly, scientists have even detected PQQ-like compounds in interstellar dust, suggesting it may have played a role in the origins of organic life.

In the human body, PQQ acts as a potent antioxidant and supports key pathways involved in mitochondrial function and cellular renewal. It’s one of the few compounds known to stimulate the growth of new mitochondria in cells, a process known as mitochondrial biogenesis.

The Role of PQQ as an Antioxidant

Antioxidants protect the body from free radicals – unstable molecules that damage DNA, proteins and cell membranes. PQQ is particularly effective because it can repeatedly cycle between oxidised and reduced forms, allowing it to neutralise free radicals multiple times before breaking down.

Studies show that PQQ not only scavenges free radicals directly but also enhances the body’s own antioxidant defences by stimulating the production of superoxide dismutase (SOD) and glutathione. These compounds help maintain cellular integrity and protect against oxidative stress, which contributes to premature ageing, inflammation and chronic disease.

PQQ and Mitochondrial Function

Mitochondria are the powerhouses of our cells, responsible for generating adenosine triphosphate (ATP) through oxidative phosphorylation. Healthy mitochondrial function underpins every aspect of physical and mental performance, from muscle endurance to cognitive focus.

PQQ supports mitochondria in two main ways. First, it helps existing mitochondria operate more efficiently by improving the transport of proteins involved in energy metabolism. Second, it stimulates the creation of new mitochondria by activating genes such as PGC-1α and Nrf1, both of which regulate mitochondrial biogenesis. This dual action enhances overall energy capacity and cellular resilience.

Research suggests that when mitochondrial density and function improve, people often experience greater stamina, reduced fatigue and improved recovery after exertion. That’s why PQQ has become a key ingredient in formulations designed to optimise metabolic health, like our Metabolic Flow.

Supporting Cognitive Function

Beyond energy metabolism, PQQ has notable effects on brain health. It helps protect neurons from oxidative stress and supports nerve growth factor (NGF) production – a protein essential for neuron development and survival. Studies indicate that PQQ may enhance memory, attention and learning capacity by improving neuronal communication and reducing inflammation within the brain.

When combined with other neuro-supportive nutrients such as CoQ10, taurine, riboflavin (B2) and thiamine (B1), PQQ works synergistically to stabilise mitochondrial membranes and sustain steady ATP production in neural tissue. This combination forms the foundation of our Metabolic Flow supplement, developed to support both mental and physical energy without relying on stimulants.

PQQ and Inflammation

Chronic low-grade inflammation is linked to fatigue, insulin resistance, joint pain and accelerated ageing. Several studies have found that PQQ can modulate inflammatory pathways by reducing levels of CRP, TNF-α and interleukin-6 – key mediators of systemic inflammation.

In human trials, participants supplementing with PQQ showed reductions in inflammatory biomarkers and improvements in perceived energy and sleep quality. These findings suggest that PQQ not only enhances mitochondrial efficiency but also helps calm the inflammatory processes that often accompany modern lifestyles.

PQQ in Nature

PQQ is found naturally in small amounts in certain foods such as kiwifruit, green peppers, parsley, papaya and fermented soy (natto). However, the quantities present in food are minimal – far below the amounts used in clinical studies. The body may also produce trace amounts, but during periods of high oxidative stress or intense metabolic demand, levels can fall short. This is why supplemental PQQ can be particularly beneficial for those under chronic stress, athletes, or individuals seeking better energy metabolism.

Our Approach: Metabolic Flow

Our Metabolic Flow formula was designed to address the biological systems that govern cellular energy, focus and recovery. Each capsule combines PQQ (5 mg) with CoQ10, taurine, creatine monohydrate, magnesium malate, ginger root and essential B vitamins (B1, B2, B3). This targeted blend supports mitochondrial performance at every stage – from electron transport and ATP synthesis to redox balance and neuroprotection.

Unlike synthetic stimulant-based energy products, Metabolic Flow works on the level of mitochondrial optimisation. That means energy is produced naturally and steadily, without spikes or crashes. It’s suitable for those seeking sustained vitality, mental clarity and post-exercise recovery support.

Safety and Usage

PQQ has demonstrated a strong safety profile in human studies, even at doses significantly higher than those typically used in supplements. Nonetheless, anyone taking medication or managing a medical condition should speak with a healthcare professional before starting a new supplement. Consistency matters most; results are typically observed after several weeks of continuous use as mitochondrial turnover occurs gradually.

Key Takeaways

  • PQQ acts as a redox cofactor and powerful antioxidant.
  • It supports mitochondrial biogenesis and improves cellular energy efficiency.
  • PQQ may enhance cognitive function and protect neurons from oxidative stress.
  • Our Metabolic Flow supplement combines PQQ with synergistic nutrients to promote energy, focus and recovery naturally.

PQQ’s ability to regenerate mitochondria, reduce inflammation and sustain antioxidant defences makes it one of the most promising compounds for long-term vitality. Our Metabolic Flow formulation captures this science in its purest, most bioavailable form – helping you optimise energy production where it truly begins: inside the cell.

Products from the article

ELIVIDE Metabolic Flow in glass jar – mitochondrial health and energy supplement with CoQ10, PQQ, taurine and B-vitamins for focus and vitality Close-up of ELIVIDE Metabolic Flow ingredients showing CoQ10, taurine, ginger root and magnesium malate – synergistic nutrients for mitochondrial energy production
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ELIVIDE Metabolic Flow in glass jar – mitochondrial health and energy supplement with CoQ10, PQQ, taurine and B-vitamins for focus and vitality Close-up of ELIVIDE Metabolic Flow ingredients showing CoQ10, taurine, ginger root and magnesium malate – synergistic nutrients for mitochondrial energy production
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AntioxidantEnergyMetabolismMitochondriaRedox

by Matt Jarosy – December 29, 2022

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It has demonstrated efficacy in supporting overall health.Ubiquinol: This is the reduced, active form of CoQ10. Ubiquinol is absorbed by the body without the need for conversion but is less stable. This is why we prefer to allow the body to perform the process of oxidation by using ubiquinone. Functions in the Human Body COQ10 it’s not like your everyday mitochondria worker and that's because it's the only component that is not anchored to the inner mitochondrial membrane allowing a certain degree of freedom. It’s also very stable making it a tough antioxidant too (similar structure to vitamin E). It can handle some unstable molecules and rustle them into place with ease. The areas in the body with the highest energy requirements have the highest CoQ10 which makes sense given its role, so for example, the heart and liver.Energy Production: One of the primary functions of CoQ10 is its involvement in the electron transport chain, a critical step in cellular respiration. This process takes place in the mitochondria, where CoQ10 facilitates the production of adenosine triphosphate (ATP), the energy currency of the cell.Cellular Health: CoQ10 plays a crucial role in maintaining the structural integrity of cell membranes, supporting overall cellular health and function. CoQ10 is transported in the bloodstream attached to VLDL and LDL cholesterol, with a plasma half-life of about 30 hours. CoQ10 is very efficient at inhibiting lipid peroxidation in LDL cholesterol.Dietary Sources of CoQ10While CoQ10 is naturally synthesized in the body, it can also be obtained through dietary sources. Foods rich in CoQ10 include:Fish: Salmon, mackerel, and sardines are excellent sources of CoQ10, providing not only this essential compound but also trace minerals.Meat: Organ meats such as liver and kidney contain high concentrations of CoQ10, making them valuable dietary sources.Whole Grains: Whole grains like wheat germ and whole wheat bread contain CoQ10, contributing to its intake through a balanced diet.Fruits and Vegetables: While the levels are lower compared to animal products, fruits like oranges and strawberries, as well as vegetables like broccoli and cauliflower, contribute to overall CoQ10 intake.Benefits of CoQ10 SupplementationCardiovascular Health: CoQ10 is often touted for its cardiovascular benefits. Studies suggest that supplementation may help lower blood pressure, reduce oxidative stress, and improve overall heart function.Anti-Aging Properties: As we age, the body's natural production of CoQ10 declines. Supplementing with CoQ10 has been linked to improved skin health, including reduced wrinkles and enhanced skin hydration.Mitochondrial Support: CoQ10's pivotal role in energy production makes it essential for mitochondrial health. Supplementation may aid in addressing conditions related to mitochondrial dysfunction, promoting overall energy and vitality.Cognitive Function: Some research suggests that CoQ10 supplementation may have neuroprotective effects, potentially slowing cognitive decline and supporting brain health.Exercise Performance: Athletes and fitness enthusiasts often turn to CoQ10 supplements to enhance endurance and reduce exercise-induced muscle damage, though more research is needed in this area. Fertility: COQ10 plays an important role in egg development and sperm health making it a top choice for those wanting to conceive. Why We Need More as We AgeAs we age, the body's ability to produce and utilize CoQ10 diminishes. This decline is particularly pronounced after the age of 30. Several factors contribute to this reduction, including lifestyle factors, medication use, and the natural aging process itself.Medication Interactions: Some medications, such as statins used to lower cholesterol, can deplete CoQ10 levels in the body. Supplementing with CoQ10 is often recommended for individuals on such medications to counteract this depletion.Increased Oxidative Stress: Aging is associated with an increase in oxidative stress, leading to higher levels of free radicals. CoQ10, as a potent antioxidant, becomes even more crucial in neutralizing these free radicals and protecting cells from damage.Decline in Mitochondrial Function: Mitochondrial dysfunction is a hallmark of aging. CoQ10's role in the mitochondria becomes increasingly vital to support cellular energy production and overall cellular health.ConclusionCoenzyme Q10, with its diverse functions and numerous benefits, emerges as a vital player in the maintenance of optimal health. Whether obtained through dietary sources or supplementation, CoQ10 is an invaluable compound that supports cardiovascular health, mitigates the effects of aging, and enhances overall well-being. As our bodies age and face increasing challenges, ensuring an adequate supply of CoQ10 becomes a proactive step towards promoting longevity and vitality. Embracing the power of CoQ10 may be a key to unlocking the secrets of aging gracefully and maintaining robust health throughout the journey of life. Our mitochondrial support complex contains 100mg of COQ10 along with a similar compound known as PQQ. References Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.  Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression.Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial. Atherosclerosis. Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials.

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Supplements That Help Reduce Histamine: Our New Histamine Metabolism Support Complex

ELIVIDE Wellness Journal – by Matt Jarosy

Supplements That Help Reduce Histamine: Our New Histamine Metabolism Support Complex

Histamine is a naturally occurring compound in your body, with a pivotal role in various physiological processes. It's a small molecule that plays a significant role in immune responses, stomach acid production, and neurotransmission. While histamine is essential for several bodily functions, an excess of it can lead to a range of uncomfortable symptoms. In this article, we will explore what histamine is, the symptoms of excess histamine, common triggers, and the enzymes responsible for metabolizing histamine. What Is Histamine? Histamine, chemically known as 2-(4-imidazolyl)ethylamine, is a neurotransmitter and a biogenic amine. It is synthesized from the amino acid histidine through a series of enzymatic reactions. Once produced, histamine is stored in specialized cells called mast cells and basophils, primarily in tissues that are in direct contact with the external environment, such as the skin, respiratory tract, and gastrointestinal tract. Symptoms of Excess Histamine Histamine plays a vital role in your immune system, helping to defend your body against pathogens. However, excessive histamine levels can lead to a range of unpleasant symptoms. This condition is known as histamine intolerance, and its symptoms can mimic allergies or other health issues. Common symptoms of excess histamine include Skin Issues: Itching, hives, redness, and eczema are frequent skin reactions to excess histamine. Histamine can cause blood vessels to dilate, leading to these visible skin changes Gastrointestinal Problems: Excess histamine can affect your stomach and intestines, causing symptoms like abdominal pain, bloating, diarrhea, and nausea. Respiratory Symptoms: Histamine can constrict airways and trigger symptoms like sneezing, congestion, and wheezing, which are often associated with allergies Headaches and Migraines: Histamine is a potent vasodilator, meaning it can expand blood vessels in the brain and lead to headaches or migraines. Cardiovascular Symptoms: Some people may experience low blood pressure and an increased heart rate due to histamine-induced blood vessel dilation Fatigue: Histamine intolerance can also lead to fatigue and a general feeling of malaise. Common Triggers of Histamine: Understanding what triggers excess histamine is crucial for managing histamine intolerance. Several factors can contribute to elevated histamine levels in the body. Diet: Certain foods are high in histamine or trigger its release. These include aged cheeses, fermented foods, alcohol, and processed or smoked meats Allergies: Allergic reactions can release large amounts of histamine in response to allergens like pollen, dust mites, or pet dander. Gut Health: An imbalance of gut bacteria can impair the breakdown of histamine in the digestive tract, leading to its accumulation Medications: Some medications, such as non-steroidal anti-inflammatory drugs (NSAIDs) and certain antacids, can interfere with histamine metabolism Stress: Stress can stimulate the release of histamine, exacerbating symptoms in individuals with histamine intolerance. Enzymes that Metabolize Histamine: In your body, histamine levels are carefully regulated by enzymes that break it down and convert it into inactive metabolites. Two key enzymes involved in histamine metabolism are: Diamine Oxidase (DAO): This enzyme is primarily responsible for breaking down histamine in the digestive tract. It's produced by the cells lining your gut and helps prevent histamine from being absorbed into the bloodstream. Histamine N-Methyltransferase (HNMT): HNMT is found in various tissues throughout the body and plays a role in metabolizing histamine in the brain and other organs. It helps regulate histamine levels in the central nervous system. When these enzymes are functioning correctly, they help maintain a balance of histamine in your body. However, genetic factors, medications, or gut health issues can impair the activity of these enzymes, contributing to histamine intolerance. Our new histamine complex uses a variety of ingredients to not only reduce the effects of histamine but also help your body metabolise it more efficiently. Including: Creatine Monohydrate - Enhancing Histamine Metabolism and Energy ProductionCreatine monohydrate indirectly promotes histamine metabolism by supporting the activity of histamine-metabolizing enzymes, such as diamine oxidase (DAO) and histamine-N-methyltransferase (HNMT). By facilitating the breakdown of histamine, creatine reduces its accumulation and helps alleviate histamine intolerance symptoms. Additionally, creatine plays a vital role in cellular energy production, ensuring optimal function and efficiency in histamine metabolism.Organic Acerola: Natural Vitamin C - Antioxidant Defense and Histamine ModulationAcerola is a rich source of natural vitamin C which is a potent antioxidant. Vitamin C protects against histamine-induced oxidative stress, which can exacerbate histamine intolerance symptoms. By neutralizing free radicals and reducing oxidative damage, vitamin C helps maintain a balanced histamine response. Furthermore, vitamin C exhibits anti-inflammatory properties and supports immune function, contributing to a well-regulated histamine system.L-Theanine - Calming Inflammation and Modulating Histamine ReleaseL-theanine, derived from green tea, exerts anti-inflammatory effects by inhibiting the activation of pro-inflammatory signaling molecules, such as nuclear factor-kappa B (NF-κB). By reducing inflammation, L-theanine helps modulate histamine release and mitigate histamine-related discomfort. Moreover, L-theanine promotes relaxation by enhancing alpha brain wave activity, which can reduce stress-induced histamine release. Bromelain - Digestive Support and Histamine BreakdownBromelain, a proteolytic enzyme found in pineapple, aids in the digestion of proteins, including histamine-rich foods. By facilitating protein breakdown, bromelain supports proper digestion and minimizes the absorption of intact histamine molecules. This digestive support helps reduce histamine accumulation in the body and alleviates digestive symptoms associated with histamine intolerance. Bromelain has also been shown to inhibit the production of pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). By reducing inflammation, bromelain may indirectly decrease the release or synthesis of histamine in certain immune cells.Boswellia - Anti-inflammatory Action and Histamine BalanceBoswellia possesses potent anti-inflammatory properties due to its active components, such as boswellic acids. By inhibiting the activity of pro-inflammatory enzymes, including 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2), boswellia helps reduce histamine-induced inflammation and promotes a balanced histamine response. This anti-inflammatory action contributes to overall histamine tolerance and alleviation of associated symptoms.Copper - The Central Atom of Histamine Metabolism EnzymesMinerals play an important role in histamine balance and copper is no exception. Copper is an essential cofactor for DAO, the primary enzyme responsible for breaking down histamine in the gut. Adequate copper levels ensure proper DAO activity, facilitating efficient histamine metabolism and preventing its accumulation.Vitamin B6 - Enzyme Co-Factor in Histamine ClearanceVitamin B6, also known as pyridoxine or P5P, plays a crucial role in the metabolism of histamine. It is a cofactor in the production of enzymes that metabolise histamine, further supporting its regulation. While vitamin B6 may not directly lower histamine levels, its role in histamine metabolism suggests that it can help alleviate the effects of histamine-related conditions, such as allergies or histamine intolerance. Bifidobacterium infantis and Bifidobacterium longum - Gut Microbiota Support for Improved Histamine ToleranceBifidobacterium infantis and Bifidobacterium longum, two beneficial probiotic strains, play a crucial role in supporting a healthy gut microbiota. By promoting a balanced microbial environment, these strains help optimize digestion and reduce histamine production in the gut. Furthermore these two specific strains have been to suppress allergic type symptoms and decrease histamine levels. Find out more here

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Fueling Your Mitochondria: Make More Energy

ELIVIDE Wellness Journal – by Matt Jarosy

Fueling Your Mitochondria: Make More Energy

Mitochondria are membranous, slightly elongated structures contained within the cytoplasm of almost all eukaryotic cells. Using aerobic respiration, they take oxygen and the compounds in our food to make energy (in the form adenosine triphosphate, known as 'ATP'). Each cell contains the appropriate amount of mitochondria relative to its energy use. That means organs such as the heart contain a lot of mitchondria, infact each cell of your heart contains around 5000 mitochondria. When we lose mitochondria or they begin to malfunction, it can increase our risk of 'dis-ease'. It is thought that mitochondria were originally independent bacterial entities which at some point over a billion years ago (through much trial and error) entered other bacterial cells and decided to partner up. This moment was monumentous, you could argue this was the beginning of complex life as we know it. Two important cycles that occur within the mitochondria for energy production are the the tricarboxylic acid cycle (TCA) and the electron transport chain (ECT). Think of these like factory lines, they need to be flowing freely in order for energy to be generated efficiently. During normal oxidative phosphrlation (whereby ATP is formed by electron transfer) about 2 percent of the oxygen consumed is converted to superoxide (a type of free radical). This is where nutrition comes, anti-oxidants from our diet help to mop up the free radicals formed by energy production. Unfortunately, making energy comes with exhaust.  So what do mitochondria need to function properly? Magnesium: In order for ATP be 'activated', it needs to form a complex with magnesium.  B Vitamins: These are like the workers on the factory line, helping to pass energy from one cycle to another. Each B vitamin has a specific role, for example riboflavin (B2) plays a key role in shuttling electrons from the TCA and cobalamin (B12) is needed to generate s-adenosyl methionine (SAMe) which is part of the protein sub unit that makes up the ECT. COQ10: You can think of COQ10 as the oil in the factory, it helps to keep things running smoothly. It can regenerate free radicals and soothe them back into the ECT. PQQ: Otherwise known as pyrroloquinoline quinone, helps control redox processes in the mitochondrial, essentially balancing oxidative stress as well as stimulating energy production. B3: We need B3 or niacinamide to manufacture NADH (energy carrier) and to supply protons for oxidative phosphorylation. Copper: Copper is a cofactor in the ECT so that ATP can be released, it also plays a key role in mitochondrial signaling and mitophagy. Given mitochondria's role in the body, mitocondrial may be the key to unlocking the process of aging itself. According to this theory, with age, mitochondria accumulate ROS-induced damage and become dysfunctional. With time, the function of cells declines causing aging and subsequent death. Many things can induce oxidative stress in humans, including not having the necessary cofactors for making energy. Remember, making energy makes exhuast. The more we can buffer this exhaust, the better.

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Organic Ingredients benefits

ELIVIDE Wellness Journal – by Matt Jarosy

Why Choose Organic? How We Select Ingredients

Why Choose Organic Ingredients? At ELIVIDE, purity begins with the source. While not every product in our range is fully certified organic, many of our formulations contain select organic ingredients — sourced from trusted suppliers and certified by the Soil Association where applicable. The Soil Association symbol remains one of the most recognised and respected marks of organic certification worldwide, guaranteeing ingredients that meet high standards for sustainability and safety. What Organic Certification Means Organic certification goes far beyond marketing. The Soil Association Organic Standard ensures that crops are grown and processed without synthetic pesticides, herbicides, or genetically modified organisms (GMOs). Instead of chemical inputs, organic farming focuses on natural systems that enrich the soil and sustain life. Rather than relying on artificial fertilisers, organic farmers improve soil fertility through compost, green manures, and crop rotation. Weeds and pests are managed by mechanical weeding, beneficial insects, and crop diversity — not through synthetic chemical sprays. This regenerative approach nurtures living soil, biodiversity, and long-term resilience. Health and Pesticide Exposure One of the key reasons we choose organic ingredients is to reduce exposure to pesticide residues commonly found on conventionally grown crops. Decades of research have raised concerns about how repeated, low-level exposure to agricultural chemicals can affect human health. A 2004 review co-authored by the U.S. National Cancer Institute concluded that “epidemiological evidence clearly suggests that, at current exposures, pesticides adversely affect human health.” Further, a 2013 report by the European Food Safety Authority (EFSA) examined over 600 studies and found strong associations between pesticide exposure and childhood leukemia, asthma, Parkinson’s disease, and certain cancers. Many pesticides are also recognised as endocrine disruptors — compounds that can interfere with hormone regulation and metabolism. While single exposures may be minor, the cumulative effect over years can impact the body’s natural balance. By using organically grown ingredients wherever possible, we significantly reduce this potential burden. Environmental Benefits of Organic Farming Choosing organic is also a choice for the planet. Organic agriculture prioritises ecological harmony, treating soil as a living system rather than an inert medium. Healthy soil captures carbon, holds water, and supports thriving microbial life — all crucial for sustainable food production. Studies consistently show that organic farms support up to 50% more wildlife abundance compared to conventional systems. Pollinators such as bees and butterflies thrive in pesticide-free environments, while natural predators keep pest populations balanced. This interconnected web of life helps restore biodiversity and protect ecosystems from chemical runoff and pollution. Why Organic Ingredients Matter in Supplements Organic plant materials don’t just reduce exposure to unwanted chemicals — they also retain a higher density of antioxidants, phytonutrients, and enzymes compared to conventionally farmed equivalents. These natural cofactors work synergistically with vitamins and minerals, supporting better nutrient absorption and biological compatibility. When sourcing for our supplements, we prioritise organic ingredients that provide wholefood complexity rather than synthetic isolates. This ensures each formulation aligns with human biology and delivers nutrients in their natural matrix — just as they occur in food. Our Approach to Organic Sourcing ELIVIDE’s goal is to combine purity, science, and sustainability. While not every ingredient can be certified organic due to availability or stability, we always prioritise organic sourcing where quality, potency, and environmental impact align. For example, our Eclipse Wholefood Vitamin C includes organic acerola, camu camu, and amla berry — three of nature’s richest vitamin C sources. Each fruit is grown using organic methods, free from synthetic pesticides or genetic modification. This ensures that every capsule delivers a pure, plant-based nutrient complex that supports immunity, collagen formation, and antioxidant protection naturally. All our formulations are additive-free, encapsulated in plant-based pullulan capsules, and produced using renewable energy in the UK. This reflects our broader mission: to create supplements that support not only personal wellbeing but also the ecosystems that sustain us. Organic for a Healthier Future Supporting organic farming practices extends benefits far beyond personal health. It encourages biodiversity, reduces pollution, and builds more resilient food systems for the future. Even when used selectively within a formulation, organic ingredients uphold principles of transparency, traceability, and environmental respect. By choosing supplements crafted with organic wholefood ingredients, you support a system that values soil, farmers, and long-term ecological balance. Every organic ingredient represents a step toward a cleaner, more sustainable way of nourishing both body and planet. In Summary While not every ELIVIDE product is fully certified organic, our commitment to purity and sustainability guides every sourcing decision we make. We use certified organic ingredients wherever possible — and always prioritise clean, additive-free, and ethically produced raw materials. Organic ingredients aren’t just a label; they represent a philosophy of integrity. At ELIVIDE, that philosophy underpins everything we do — creating supplements that work in harmony with your body and with nature itself.

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Stress and magnesium levels

ELIVIDE Wellness Journal – by Matt Jarosy

How Stress Affects Your Magnesium Levels

How Stress Affects Your Magnesium Levels One of the most common questions we’re asked is: do we need more magnesium when we’re stressed? The short answer is yes — but to understand why, we first need to look at what happens in the body when we experience stress. The Physiology of Stress Stress has a profound and immediate effect on the body. When we face physical or emotional challenges, the sympathetic nervous system — often called the “fight or flight” system — activates to prepare us for action. This response releases hormones like adrenaline and cortisol, increases heart rate and blood pressure, and diverts blood flow to the muscles and brain. Calcium floods into our muscles to prepare for contraction, glucose is mobilised from energy stores, and cortisol keeps energy levels stable over time. This is a remarkable and necessary adaptation — one that has allowed our species to survive. Without cortisol, we wouldn’t even be able to wake up in the morning. However, while stress is essential in short bursts, it is also highly energy-intensive and places significant demands on key nutrients — especially magnesium. Magnesium: The Energy Mineral Magnesium is required for over 300 enzymatic reactions in the human body, including those responsible for energy production, muscle relaxation, and nervous-system regulation. Every molecule of ATP — the body’s main energy currency — must be bound to magnesium to be biologically active. Without magnesium, energy metabolism simply can’t function properly. Magnesium is the fourth most abundant mineral in the body and the second most concentrated inside our cells. It’s within these cells that most of our energy processes take place. During stress, the increased energy demand leads to a greater turnover of magnesium, meaning we use up our reserves more rapidly. How Stress Depletes Magnesium Research consistently shows that stress and magnesium deficiency reinforce each other — each one worsening the effects of the other. When stress hormones rise, urinary magnesium excretion increases, effectively flushing this essential mineral from the body. This creates a vicious cycle: the more stressed you are, the lower your magnesium levels become, which in turn makes your nervous system more reactive to stress. A 2018 review in the International Journal of Molecular Sciences highlighted how acute stress elevates plasma magnesium levels temporarily but also increases urinary loss shortly after. Over time, this can lead to hypomagnesemia — low magnesium levels in blood and tissue. This depletion is associated with a range of stress-related conditions including migraines, fibromyalgia, anxiety, and chronic fatigue. Because magnesium plays such a vital role in nerve and muscle function, deficiency can intensify symptoms of tension, irritability, and sleep disturbance — all of which are common under chronic stress. Recognising Daily Stress Stress isn’t limited to emotional strain. It can be physical (intense exercise, lack of sleep, or illness), mental (work pressure, relationships), or environmental (noise, pollution, or light exposure). Each stressor triggers a similar hormonal cascade and uses up magnesium in the process. Take a moment to think about your daily life — caffeine, tight schedules, training sessions, and screens late at night. Each of these adds small but cumulative stress loads. Supporting your magnesium status helps buffer these everyday demands and maintain nervous-system equilibrium. How to Replenish Magnesium Naturally The first step to restoring magnesium levels is through food. Excellent dietary sources include: Leafy green vegetables (ollard greens) Avocados, bananas, and fruits Soaked nuts and seeds (pumpkin, sunflower, almonds) Dark chocolate (70% or higher) Magnesium can also be obtained from natural mineral water in the form of magnesium bicarbonate or magnesium chloride, though most modern tap water contains very little. Unfortunately, soil depletion and industrial agriculture have reduced magnesium content in many foods, making supplementation a valuable complement to diet. Transdermal Absorption and Relaxation One of the most soothing ways to boost magnesium is through the skin. Bathing with magnesium chloride flakes allows the mineral to be absorbed transdermally — directly into the bloodstream. Many people find magnesium baths incredibly relaxing, both physically and mentally, as they deliver magnesium efficiently while also activating the parasympathetic (“rest and digest”) system. Think of it as a natural “reset” — you’re replenishing magnesium while simultaneously calming the very system that stress activates. Choosing the Right Magnesium Supplement When it comes to supplementation, not all magnesium forms are equal. Some forms, such as magnesium oxide, have poor absorption and can irritate the gut. The most effective and gentle options are chelated forms such as bisglycinate, malate, and taurate. At ELIVIDE, we offer several clean, additive-free formulations designed for specific goals. Our Magnesium Bisglycinate Food is ideal for relaxation and sleep support, while Magnesium Malate Food supports energy production and recovery. Each serving provides 130–160 mg of elemental magnesium, blended with organic evaporated coconut water for improved hydration and mineral synergy. Be cautious when comparing supplement labels — some brands list the total compound weight (including what magnesium is bound to) rather than the actual elemental magnesium content. What matters is how much usable magnesium your body receives, not the total tablet weight. Integrating Magnesium into Your Daily Routine To support resilience and reduce stress reactivity: Include magnesium-rich foods at each meal. Consider evening supplementation with magnesium bisglycinate to support calm and sleep. Take regular magnesium baths or use topical sprays for added support. Stay hydrated and minimise stimulants like caffeine that deplete magnesium. Practice relaxation techniques (breathing, walking, time outdoors) to reduce the body’s demand for stress-related magnesium turnover. Stress and magnesium are intimately linked — each influencing the other. Chronic stress increases magnesium loss, while magnesium deficiency heightens stress sensitivity. Maintaining optimal magnesium levels supports calm, balanced energy, and a healthy nervous system. By eating well, staying hydrated, and choosing bioavailable magnesium forms such as bisglycinate or malate, you can strengthen your resilience and protect your body from the physiological wear and tear of modern life. It’s a simple step with profound effects on overall wellbeing.

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What Is Iodine? The Halogen Inside Each Of Your Cells

ELIVIDE Wellness Journal – by Matt Jarosy

What Is Iodine? The Halogen Inside Each Of Your Cells

In conjuction with the release of our latest supplement, we wanted to talk a little bit more about Iodine. Our new organic seaweed blend contains 346ug of wholefood iodine which equates to 230% of the RNI (reference nutrient intake), but why do we need it? and what really is iodine? Bernard courtois was the man who first discovered iodine which is a halogen if you're looking at the periodic table. He was originally making gunpowder from potassium and sodium but accidentally added too much sulphuric acid to seaweed ash and observed a distinct purple colour. This was the birth of iodine ('iodes' in greek means violet-coloured).  There are naturally occurring non-radioactive and radioactive iodine forms. Radioactive iodine has uses in medicine to diagnose and treat certain conditions whereas natural forms come in many sources like seaweed.  In human health iodine is often misunderstood. It is a micronutrient that is found in each of your cells but is a relatively rare earth element ranking 62. It is typically concentrated in sea organisms such as seaweed which means the further inland you go, the further you get away from iodine and the more prevalent iodine deficiency becomes. This is highlighted by what was known as 'the goilter belt' (areas within Great Lakes, Appalachian, and Northwestern U.S. regions etc) which had high prevalences of iodine deficiency. Goiter is an enlarged thyroid gland; when a gland doesn’t get what it needs, it typically increases its surface area in an attempt to find more of its missing micronutrient, in this case iodine. In order to combat the epidemic of goiter happening worldwide governments began adding iodine to salt products (iodized salt) and although this did have an impact on the prevalence of goiter, it did not address the wider issues. Between 1970s - 2000 studies by NHANES still showed a 50% drop in iodine levels across the US (similar figures in many parts of europe) with the percentage of pregnant women with low iodine concentrations increasing 690% over this time period. The question is, why was this? This was likely due to a couple of different reasons including reduced dietary intake and exposure to other halides such as bromide and flouride. Specific functions of iodine Iodine is an essential ingredient for thyroid hormones thyroxine (T4) and triiodothyronine (T3) which are key hormones in the regulation of your metabolic rate. Every single cell in your body depends on adequate levels of thyroid hormone.  Deficiencies or overdoses of iodine are risk factors in hypothyroidism and autoimmune diseases like Graves and Hashimotos. Iodine is not found in large quantities in the body although there’s around 15-20mg in the thyroid of an average adult. The thyroid gland concentrates it there using a system known as the sodium/iodide symporter (NIS) of which the mammary glands have the same mechanism for concentrating iodine. But it's not just the thyroid gland, iodine might just be one of, if not the most important micronutrient for breast health. There is a wealth of research showing the connection between iodine deficiency and breast cancer. As mentioned, the breasts also have a sodium/iodide transport system, concentrating iodine there. The concentration of iodine in mammary glands and its secretion here highlights the importance of iodine. Low levels conclusively cause changes to the structure and function of the breasts. It’s worth noting that in animal studies, iodide is ineffective at reversing pre-cancerous lesions of breast tissue whereas iodine is much more effective.  Iodine also helps prevent lipoperoxidation (the oxidation of lipids) which has been found to be elevated in breast tumours and can help balance estrogen by maintaining the estrogen/estriol ratio. When there is an imbalance in estrogen ratios (estrone, estriol and estrogen), women can suffer from things like fibrocystic breasts, a condition where breasts have cysts which are usually painful to touch. In cancer, iodine has the ability to induce apoptosis, the process of timed cell death which is essential for the regulation of cancer in the body. It does this through a few mechanisms like the iodination of lipids. It really does pack a punch in the anti-oxidant department.  Why we might need more iodine now One of the issues around halogens is that they like to compete in the body. Other halides, particularly bromide and fluoride can bind to iodine receptors in the body, blocking absorption. Bromide has no place in the body. It is a toxic compound which is used as a flame retardant in many furnishings and in baked goods as a dough conditioner. Fluoride is also added to many water supplies to help strengthen teeth but it comes at a cost. Furthermore, perchlorate, another halogen which contains one atom of chlorine and four atoms of oxygen, further displaces iodine. Perchlorate has contaminated many water supplies due to poor disposal. It is used in a variety of products like air bags, leather tanning, fireworks and in rocket fuel. The introduction of these compounds, on top of low dietary intake is a recipe for deficiencies. This is one of the reasons why some scientists believe the RNI is inadequate.

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Low magnesium in the body

ELIVIDE Wellness Journal – by Matt Jarosy

Low Magnesium and Its Impact on the Body

Magnesium often gets labelled as the “relaxation mineral”, but its role extends far beyond stress relief. It’s required for hundreds of enzymatic reactions that regulate energy, muscle function, and cellular balance. While most people know magnesium is essential, few realise the deeper implications of long-term deficiency. Let’s explore how low magnesium affects key systems throughout the body. Cardiovascular System The heart is one of the most magnesium-dependent organs in the body. It requires a constant supply of energy to maintain rhythmic contractions and electrical activity. Magnesium works in tandem with calcium — calcium triggers contraction, while magnesium allows relaxation. When magnesium levels drop, calcium regulation becomes impaired, increasing the likelihood of vascular stiffness and arterial calcification. Low magnesium levels are also linked with elevated blood pressure, arrhythmias, and endothelial dysfunction. As calcium accumulates in cells, arteries become prone to vasospasms, reducing elasticity and oxygen flow. Magnesium deficiency can also lower the membrane potential through sodium and calcium imbalance, disrupting the heart’s normal electrical rhythm. This is why adequate magnesium intake is so critical for cardiovascular health and overall vascular resilience. Inflammation and Immune Response Magnesium deficiency impacts the immune system in multiple ways. One major effect is reduced production of glutathione, the body’s master antioxidant. When glutathione synthesis declines, oxidative stress rises and calcium builds up inside cells. This cascade triggers the release of inflammatory cytokines and interleukins, which can damage the endothelial lining and promote chronic inflammation. Low magnesium also weakens the immune system’s ability to respond to viral challenges. Research suggests that insufficient magnesium can impair natural killer cell function and increase the likelihood of latent viral reactivation, including Epstein-Barr virus (EBV). Maintaining magnesium sufficiency supports balanced immune activity, helping the body regulate inflammation without tipping into overactivation. Conversion Pathways and Vitamin D Magnesium is a required cofactor for the activation and metabolism of vitamin D. Without enough magnesium, the body struggles to convert vitamin D from its inactive storage form (25-hydroxyvitamin D) to its active hormonal form (1,25-dihydroxyvitamin D). This conversion is essential for calcium homeostasis, immune modulation, and bone integrity. When magnesium is deficient, even high doses of vitamin D supplementation may not function as intended. This explains why individuals with low magnesium sometimes experience persistently low active vitamin D levels despite supplementation. During periods of stress or infection, when vitamin D activation should increase, magnesium deficiency can blunt this protective response. Liver Function and Detoxification The liver is a high-energy organ, performing thousands of chemical reactions every hour to neutralise toxins, regulate hormones, and process nutrients. These reactions depend on ATP — and ATP must be bound to magnesium to be biologically active. In low magnesium states, ATP synthase activity is reduced, which directly impairs detoxification capacity. Research shows that low magnesium status is common in non-alcoholic fatty liver disease (NAFLD) and that supplementation may help improve liver enzyme balance and reduce oxidative stress. Magnesium also appears to protect against bile duct ligation-induced liver injury by stabilising cell membranes and reducing inflammatory infiltration. In short, magnesium is indispensable for efficient liver detoxification and metabolic stability. Magnesium Deficiency and Modern Living Chronic stress, poor soil mineral content, caffeine, and certain medications (such as proton-pump inhibitors or diuretics) all contribute to low magnesium intake or increased excretion. Over time, this cumulative depletion can affect multiple systems — cardiovascular, immune, neurological, and hepatic. Symptoms like muscle tightness, fatigue, poor sleep, or heightened stress response often trace back to suboptimal magnesium status. Dietary sources such as leafy greens, soaked nuts and seeds, avocados, and whole grains remain foundational, but modern diets rarely supply enough. Supplementing with well-tolerated forms like Magnesium Malate Food or Magnesium Bisglycinate Food can help restore balance, support energy metabolism, and counteract the physiological drain of modern stressors. Both of these forms are fully reacted chelates, additive-free, and blended with organic evaporated coconut water for mineral synergy, a hallmark of our clean, bioavailable formulations. Maintaining healthy magnesium levels is one of the simplest yet most effective ways to support the heart, calm inflammation, optimise vitamin D function, and sustain detoxification. It’s not a quick fix, it’s a foundational element of long-term resilience and cellular balance.

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Benefits of Taurine For Cellular Health

ELIVIDE Wellness Journal – by Matt Jarosy

Taurine: The Sulphur Amino Acid for Calm, Focus and Cellular Health

Taurine is one of those nutrients that quietly supports almost every major system in the body, yet often goes unnoticed. It’s an amino sulfonic acid, commonly referred to as an amino acid, though it doesn’t form part of structural proteins. Instead, taurine acts as a functional molecule - influencing the heart, brain, liver and mitochondria. What is Taurine? Taurine is found abundantly in animal tissues, and is the most concentrated free amino acid in the human body. It’s highest in the heart and brain, followed by skeletal muscle and the eyes. Even breast milk contains taurine to support infant brain and retinal development. Unlike amino acids such as leucine or glycine, taurine isn’t used to build new tissue. It’s considered a conditionally essential amino acid - meaning your body can make small amounts from cysteine and methionine, but under stress or illness, your demand far exceeds what you can synthesise. Taurine is only naturally present in animal foods like eggs, beef, shellfish and turkey. That means vegans and plant-based eaters are at higher risk of deficiency. Why Taurine Appears in Energy Drinks Many people first encounter taurine through energy drinks, which include it for its ability to enhance mental focus and reduce fatigue. Despite popular myths, taurine doesn’t come from bull urine — its name simply derives from the Latin word taurus, meaning bull or ox. In reality, taurine’s benefits extend far beyond stimulation — it supports steady energy, nervous system balance and metabolic protection. Key Roles of Taurine in the Body Taurine plays a remarkably diverse role in maintaining physiological balance. Its key functions include: Supporting magnesium utilisation within cells. Assisting copper and liver metabolism. Promoting healthy estrogen detoxification. Helping regulate cholesterol and bile acid production. Maintaining cellular hydration and electrolyte balance. Regulating insulin sensitivity and glucose metabolism. Modulating the central nervous system by interacting with GABA and glutamate receptors. Protecting mitochondria from oxidative stress and reactive oxygen species. Through these mechanisms, taurine contributes to both metabolic and emotional stability - influencing energy levels, detoxification, hormone regulation and mood. Taurine, GABA and Sleep Taurine acts as a natural neuromodulator in the brain. It interacts with GABA receptors - the same calming neurotransmitter pathways that magnesium supports - helping the nervous system relax and unwind. By balancing excitatory and inhibitory activity, taurine can promote deeper, more restorative sleep and reduce symptoms of overstimulation. For this reason, many people find taurine helpful before bed. However, it can also be used in the morning to enhance calm focus and mental clarity — it works adaptively depending on your state. Our Approach to Taurine Supplementation Taurine is featured in two of our formulations: Our Magnesium Taurate - combines magnesium with around 400 mg of taurine per serving to support heart health, performance recovery and relaxation. This form delivers gentle, sustained mineral replenishment alongside taurine’s nervous system benefits. Our Metabolic Flow includes taurine alongside CoQ10, PQQ and magnesium malate for mitochondrial support and cellular energy balance. Both are crafted to deliver taurine in bioavailable, balanced forms without synthetic additives - part of our commitment to additive-free, biologically intelligent supplementation. How Much Taurine Should You Take? While our magnesium taurate provides a meaningful base, many athletes and active individuals choose to supplement additional taurine. A typical daily range is 500 mg to 3,000 mg. Doses above this may cause digestive discomfort or mild dizziness in sensitive individuals, so it’s best to start low and assess tolerance. If you’re taking medications, particularly those affecting blood pressure or insulin, consult your healthcare professional before supplementing. Final Thoughts Taurine plays a quietly powerful role in how we feel and function day to day. From balancing electrolytes to calming the nervous system and protecting mitochondria, it’s one of those nutrients that bridges the gap between stress, performance and recovery. Whether for sleep, mental clarity or endurance, taurine offers a broad foundation for modern wellbeing - especially when paired with magnesium for full mineral synergy.

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