by Matt Jarosy
Pyrroloquinoline quinone (PQQ): From Stardust to Mitochondria
We recently launched our mitochondrial support supplement, Metabolic Flow, which contains a unique compound called Pyrroloquinoline Quinone (PQQ). In this article, we’ll explore what PQQ is, how it works, and why it’s such an intriguing nutrient for cellular energy, brain function and overall vitality. What is PQQ? PQQ is a naturally occurring molecule found in plants, bacteria and some animal tissues. Structurally similar to a vitamin, it functions as a redox cofactor – meaning it assists in chemical reactions involving electron transfer. These reactions are essential for generating energy and protecting cells from oxidative damage. Interestingly, scientists have even detected PQQ-like compounds in interstellar dust, suggesting it may have played a role in the origins of organic life. In the human body, PQQ acts as a potent antioxidant and supports key pathways involved in mitochondrial function and cellular renewal. It’s one of the few compounds known to stimulate the growth of new mitochondria in cells, a process known as mitochondrial biogenesis. The Role of PQQ as an Antioxidant Antioxidants protect the body from free radicals – unstable molecules that damage DNA, proteins and cell membranes. PQQ is particularly effective because it can repeatedly cycle between oxidised and reduced forms, allowing it to neutralise free radicals multiple times before breaking down. Studies show that PQQ not only scavenges free radicals directly but also enhances the body’s own antioxidant defences by stimulating the production of superoxide dismutase (SOD) and glutathione. These compounds help maintain cellular integrity and protect against oxidative stress, which contributes to premature ageing, inflammation and chronic disease. PQQ and Mitochondrial Function Mitochondria are the powerhouses of our cells, responsible for generating adenosine triphosphate (ATP) through oxidative phosphorylation. Healthy mitochondrial function underpins every aspect of physical and mental performance, from muscle endurance to cognitive focus. PQQ supports mitochondria in two main ways. First, it helps existing mitochondria operate more efficiently by improving the transport of proteins involved in energy metabolism. Second, it stimulates the creation of new mitochondria by activating genes such as PGC-1α and Nrf1, both of which regulate mitochondrial biogenesis. This dual action enhances overall energy capacity and cellular resilience. Research suggests that when mitochondrial density and function improve, people often experience greater stamina, reduced fatigue and improved recovery after exertion. That’s why PQQ has become a key ingredient in formulations designed to optimise metabolic health, like our Metabolic Flow. Supporting Cognitive Function Beyond energy metabolism, PQQ has notable effects on brain health. It helps protect neurons from oxidative stress and supports nerve growth factor (NGF) production – a protein essential for neuron development and survival. Studies indicate that PQQ may enhance memory, attention and learning capacity by improving neuronal communication and reducing inflammation within the brain. When combined with other neuro-supportive nutrients such as CoQ10, taurine, riboflavin (B2) and thiamine (B1), PQQ works synergistically to stabilise mitochondrial membranes and sustain steady ATP production in neural tissue. This combination forms the foundation of our Metabolic Flow supplement, developed to support both mental and physical energy without relying on stimulants. PQQ and Inflammation Chronic low-grade inflammation is linked to fatigue, insulin resistance, joint pain and accelerated ageing. Several studies have found that PQQ can modulate inflammatory pathways by reducing levels of CRP, TNF-α and interleukin-6 – key mediators of systemic inflammation. In human trials, participants supplementing with PQQ showed reductions in inflammatory biomarkers and improvements in perceived energy and sleep quality. These findings suggest that PQQ not only enhances mitochondrial efficiency but also helps calm the inflammatory processes that often accompany modern lifestyles. PQQ in Nature PQQ is found naturally in small amounts in certain foods such as kiwifruit, green peppers, parsley, papaya and fermented soy (natto). However, the quantities present in food are minimal – far below the amounts used in clinical studies. The body may also produce trace amounts, but during periods of high oxidative stress or intense metabolic demand, levels can fall short. This is why supplemental PQQ can be particularly beneficial for those under chronic stress, athletes, or individuals seeking better energy metabolism. Our Approach: Metabolic Flow Our Metabolic Flow formula was designed to address the biological systems that govern cellular energy, focus and recovery. Each capsule combines PQQ (5 mg) with CoQ10, taurine, creatine monohydrate, magnesium malate, ginger root and essential B vitamins (B1, B2, B3). This targeted blend supports mitochondrial performance at every stage – from electron transport and ATP synthesis to redox balance and neuroprotection. Unlike synthetic stimulant-based energy products, Metabolic Flow works on the level of mitochondrial optimisation. That means energy is produced naturally and steadily, without spikes or crashes. It’s suitable for those seeking sustained vitality, mental clarity and post-exercise recovery support. Safety and Usage PQQ has demonstrated a strong safety profile in human studies, even at doses significantly higher than those typically used in supplements. Nonetheless, anyone taking medication or managing a medical condition should speak with a healthcare professional before starting a new supplement. Consistency matters most; results are typically observed after several weeks of continuous use as mitochondrial turnover occurs gradually. Key Takeaways PQQ acts as a redox cofactor and powerful antioxidant. It supports mitochondrial biogenesis and improves cellular energy efficiency. PQQ may enhance cognitive function and protect neurons from oxidative stress. Our Metabolic Flow supplement combines PQQ with synergistic nutrients to promote energy, focus and recovery naturally. PQQ’s ability to regenerate mitochondria, reduce inflammation and sustain antioxidant defences makes it one of the most promising compounds for long-term vitality. Our Metabolic Flow formulation captures this science in its purest, most bioavailable form – helping you optimise energy production where it truly begins: inside the cell.
