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Unlocking the Power of Pomegranates: A Superfruit for Health and Wellness

by Matt Jarosy – January 20, 2025

Unlocking the Power of Pomegranates: A Superfruit for Health and Wellness

In light of our recent formulation, Eclipse C, we wanted to dive into the benefits of pomegranates. Pomegranates, with their ruby-red seeds and sweet-tart flavor, have long been celebrated for their taste and visual appeal. Yet, beyond their culinary allure lies a treasure trove of health benefits, supported by scientific research and centuries of traditional use. Rich in essential nutrients, bioactive compounds, and antioxidants, pomegranates have earned their place as a true superfruit. We will be paying special attention to their unique compounds like punicalagins, and explore why pomegranate extract—particularly water-extracted forms—is a convenient and powerful way to harness these benefits.

The Nutritional Profile of Pomegranates

Pomegranates are a nutrient-dense fruit, providing vitamins, minerals, and bioactive compounds in abundance. A 100-gram serving of pomegranate arils (the edible seeds) contains:

Calories: 83
Protein: 1.7 grams
Fiber: 4 grams
Vitamin C: 10% of the Daily Value (DV)
Vitamin K: 36% of the DV
Potassium: 12% of the DV

Pomegranates are also rich in polyphenols, a group of powerful antioxidants. Key among these are punicalagins, anthocyanins, and ellagic acid, which contribute to the fruit’s health-promoting properties.

The Star Compound: Punicalagins

Punicalagins are unique to pomegranates and are one of the primary reasons this fruit is so special. These water-soluble compounds are found in both the peel and juice of the fruit and are extraordinarily potent antioxidants. In fact, studies have shown that pomegranate juice’s antioxidant activity is three times higher than that of red wine or green tea.**

Health Benefits of Punicalagins:

Cardiovascular Health: Punicalagins have been shown to support heart health by improving endothelial function and reducing arterial plaque. A 2004 study published in Clinical Nutrition found that patients with carotid artery stenosis who consumed pomegranate juice for three years experienced a significant reduction in arterial plaque thickness and improved cholesterol profiles.
Anti-inflammatory Effects: Chronic inflammation is at the root of many diseases, including arthritis, diabetes, and heart disease. Punicalagins exhibit powerful anti-inflammatory effects, helping to reduce markers of inflammation in the body.
Cancer Prevention: Research has highlighted punicalagins' role in inhibiting the growth of cancer cells. A study published in Molecular Cancer Therapeutics found that pomegranate extract could suppress the proliferation of prostate cancer cells and even induce apoptosis (cell death).

Ellagic Acid and Urolithins: A Metabolic Symphony

Ellagic acid, another key component of pomegranates, is metabolized by gut bacteria into compounds known as urolithins. These metabolites have garnered significant attention for their ability to enhance mitochondrial function and support cellular health.

Benefits of Ellagic Acid and Urolithins:

Anti-Aging Properties: Urolithins have been shown to stimulate mitophagy, the process by which damaged mitochondria are recycled. This mechanism is linked to improved energy production and cellular longevity.
Gut Health: Ellagic acid’s transformation into urolithins underscores the importance of gut microbiota. Healthy gut bacteria can enhance the production of these beneficial compounds, contributing to overall wellness.
Neuroprotection: Emerging studies suggest that urolithins may have neuroprotective effects, potentially reducing the risk of neurodegenerative diseases like Alzheimer’s.

Antioxidant Powerhouse: Fighting Oxidative Stress

Oxidative stress occurs when there’s an imbalance between free radicals and antioxidants in the body, leading to cell damage. Pomegranates’ high antioxidant content combats oxidative stress, offering protection against a range of chronic conditions, including:

Heart Disease: Antioxidants help prevent the oxidation of LDL cholesterol, a key factor in the development of atherosclerosis.
Cancer: By neutralizing free radicals, pomegranate antioxidants reduce DNA damage, a precursor to cancer development.
Skin Aging: Pomegranate extract has been shown to improve skin elasticity and hydration, promoting a youthful appearance.

Cardiovascular Benefits: Supporting a Healthy Heart

Heart disease remains the leading cause of death worldwide, but pomegranates may offer a natural defense. Several studies have highlighted their cardiovascular benefits:

Blood Pressure: A study in the journal Phytotherapy Research found that drinking pomegranate juice significantly reduced systolic and diastolic blood pressure.
Cholesterol Management: Pomegranate compounds help lower LDL cholesterol while increasing HDL cholesterol, contributing to better lipid profiles.
Improved Circulation: The fruit’s ability to enhance nitric oxide production promotes vasodilation, improving blood flow and reducing the risk of clots.

Joint and Bone Health: Easing Inflammation

Arthritis and other inflammatory joint conditions can severely impact quality of life. Pomegranates’ anti-inflammatory properties offer relief by:

Reducing Cartilage Damage: Studies suggest that pomegranate extract can inhibit enzymes that degrade cartilage.
Alleviating Symptoms: Pomegranate’s polyphenols help reduce pain and swelling associated with arthritis.

Immune Support: A Natural Shield

The immune-boosting properties of pomegranates are attributed to their high vitamin C content and bioactive compounds. These components:

Enhance Immune Cell Function: Vitamin C supports the production of white blood cells, crucial for fighting infections.
Antimicrobial Effects: Pomegranate extract has been shown to combat bacterial and viral infections, making it a valuable ally during cold and flu season.

Cognitive Health: Nourishing the Brain

Cognitive decline is a growing concern as the global population ages. Pomegranates may help preserve brain function and prevent neurodegenerative diseases:

Memory Enhancement: A study published in Evidence-Based Complementary and Alternative Medicine found that pomegranate juice improved memory performance in older adults.
Protection Against Alzheimer’s: The fruit’s antioxidants help reduce beta-amyloid plaques, a hallmark of Alzheimer’s disease.

Pomegranate Extract: A Concentrated Solution

While fresh pomegranates are undeniably beneficial, they’re not always convenient or accessible. This is where pomegranate extract shines. Our water-extracted pomegranate supplement provides all the goodness of this superfruit in a concentrated, easy-to-use form.

Why Choose Water-Extracted Pomegranate Extract?

Purity: Water extraction preserves the integrity of punicalagins and other bioactive compounds without the use of harsh solvents.
Potency: A concentrated extract ensures you receive a therapeutic dose of pomegranate’s beneficial compounds in every serving.
Convenience: No peeling, deseeding, or mess—just pure, pomegranate-powered nutrition.

Scientific Backing for Pomegranate Extract

Numerous studies support the efficacy of pomegranate extract in promoting health:

Prostate Health: Research published in Prostate Cancer and Prostatic Diseases found that pomegranate extract slowed the progression of prostate cancer in men with rising PSA levels.
Exercise Recovery: A study in Nutrients demonstrated that pomegranate extract reduced muscle soreness and improved strength recovery after exercise.
Skin Health: Clinical trials have shown that pomegranate extract enhances skin elasticity and hydration, making it a popular ingredient in anti-aging formulations.

For those seeking a convenient way to reap these benefits, our water-extracted pomegranate extract in our Eclipse C offers a potent and pure solution. Backed by science and crafted with care. Zero additives as always.

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Antioxidant polyphenols Vitamin C

by Matt Jarosy – January 20, 2025

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News – by Matt Jarosy

Is it bio-available? Optimising Absorption of Food & Supplements

Bioavailability is a fundamental concept in nutrition and pharmacology, describing the proportion of a nutrient or active ingredient that enters the bloodstream when introduced into the body and is thus able to have an active effect. In simple terms, even if we ingest a high quantity of a particular nutrient, only a certain amount might actually be absorbed and utilised by our body. This makes bioavailability a crucial factor in ensuring that the nutrients or compounds we consume can truly benefit us. Here at ELIVIDE I talk a lot about the bioavailability of many supplements on the market. In fact it was one of the big reasons I started ELIVIDE after seeing that much of the market was using poorly absorbable nutrient forms and additives that negatively affected digestion. But what about the food we ingest? Bioavailability is vital in food because it determines the actual nutritional benefit we gain from what we eat.Even foods that are nutritionally dense may not deliver all their benefits if their nutrients are poorly absorbed. For instance, leafy greens like spinach are high in calcium, but due to the presence of oxalates—a compound that binds to calcium and inhibits absorption—the bioavailability of calcium from spinach is lower than its face value. So how can we improve bioavailability? When I work with clients, I'm always thinking about ways to optimise their absorption of food, before I even think about changing the diet. We can be eating the healthiest food in the world but we might not be absorbing it. Here's my top tips for making sure you get the most out of your food.Chewing You have probably heard this many times before but chewing is essential for digesting food properly. Did you know that carbohydrate digestion starts in the mouth? The more we chew, the more we signal our stomach to produce acid and our pancreas to start making digestive enzymes. Both of which are essential for increasing how much we absorb. Aim for 20 chews per mouthful. Liquid intakeBe mindful of drinking too many fluids near to eating, ideally 20 minutes before and after food refrain from drinking too many fluids. A few sips is absolutely fine but just to be aware that drinking to many fluids can dilute our stomach acid and digestive enzymes. Drinking a lot of fluids during a meal can also lead to feeling uncomfortably full or bloated, which may hinder digestion by causing an overly stretched stomach.TimingThere's nothing more your body loves than routine as its always looking to predict your next move so it can prepare better, at least physiologically speaking. If you can eat at the same time each day, you will find more consistent hunger patterns and likely better digestion as a result. Keeping a routine isn't easy in this day and age but aim for a 30 minute window at each eating interval.BreathingAre you breathing through your mouth the majority of the time? Breathing through your mouth increases activation of the sympathetic nervous system (SNS), sometimes referred to as our fight and flight system. Think of it this way, the only time you would breath through your mouth is when you are running at the peak of your breath, at least thats when it should happen. It's a bit like simulating running for your life. Our SNS is not interested in digesting food and therefore shuts down digestive processes. Try to get into the habit of breathing deeply through your nose during the day and also whilst you eat. This will help make your body feel safe enough to digest properly.There's plenty more one can think about when considering bioavailability but these are great tips to consider that don't even involve changing your food. And don't forget, if we can optimise digestion of food, we can also increase the absorption of the supplements we consume.

News – by Matt Jarosy

Skin Mineral: Nourishing From The Inside Out

In the quest for healthier, more vibrant hair, skin, and nails, nature has always provided an abundant supply of nutrients. Harnessing the power of the ocean and the land, our revolutionary new supplement combines the benefits of desiccated oyster extract, organic kelp, organic acai berry, and wild-caught marine collagen to offer a potent support for your beauty needs. This all-natural, additive-free supplement is crafted with organic ingredients, ensuring the highest quality and bioavailability. Let’s dive into the amazing benefits of these superfoods and how they support your beauty from the inside out.The Power of Desiccated Oyster Extract Oysters are often celebrated for their aphrodisiac properties, but they are also a powerhouse of nutrients that are essential for healthy hair, skin, and nails. Desiccated oyster extract is rich in zinc, selenium, iron, and B vitamins, particularly B12. Zinc: Essential for cell division and growth, zinc helps maintain the structural integrity of hair, skin, and nails. It also plays a crucial role in the synthesis of collagen and keratin, the proteins that make up these tissues. Selenium: This mineral supports antioxidant enzymes, protecting cells from damage and contributing to a youthful complexion. Copper: Vital for oxygen transport, iron ensures that your hair follicles receive adequate oxygen, promoting growth and strength. Vitamin B12: Crucial for cell production and energy metabolism, B12 helps keep your skin glowing and your nails strong. The Benefits of Organic Kelp Organic kelp is a type of seaweed packed with a variety of essential nutrients, including iodine, calcium, and vitamins A, C, and E. Iodine: Necessary for thyroid function, iodine helps regulate metabolism, which can impact hair growth and overall skin health. Calcium: Supports cell renewal and the production of sebum, the natural oil that keeps your skin and scalp moisturized. Vitamins A, C, and E: These vitamins are powerful antioxidants that protect the skin from free radical damage, promote collagen production, and enhance skin elasticity and hydration. The Superfood Strength of Organic Acai Berry Acai berries are renowned for their high antioxidant content, along with vitamins and healthy fats that contribute to skin, hair, and nail health. Antioxidants: Acai berries contain anthocyanins, which fight oxidative stress and protect against aging and damage from environmental factors. Vitamin A precusors: Promotes skin repair and regeneration, helping to reduce the appearance of fine lines and wrinkles. Omega-3, 6, and 9 fatty acids: These healthy fats nourish the skin, making it supple and hydrated, while also supporting scalp health and hair strength. The Collagen Boost from Wild-Caught Marine Collagen Collagen is the most abundant protein in the body, essential for the structure and elasticity of the skin, as well as the strength of hair and nails. Wild-caught marine collagen is sourced from fish, providing a sustainable and highly bioavailable form of this crucial protein. Amino Acids: Marine collagen is rich in glycine, proline, and hydroxyproline, amino acids that are key components of collagen. These amino acids help maintain skin elasticity, reduce wrinkles, and support hair and nail growth. Bioavailability: Marine collagen is more easily absorbed by the body compared to other sources, ensuring that your body can efficiently use the nutrients to repair and strengthen tissues. Why Bioavailability Matters Bioavailability refers to the extent and rate at which the active ingredients of a supplement are absorbed and utilized by the body. High bioavailability means that more of the nutrients in the supplement are available for the body to use. As always our new supplement’s use of organic and natural ingredients to enhance its bioavailability, ensuring that you receive the maximum benefit from each dose. The absence of additives further ensures that nothing interferes with the absorption and effectiveness of these vital nutrients.Pure, Organic, and Additive-Free In a market flooded with supplements, it’s crucial to choose one that prioritizes quality and purity. This supplement is free from additives, fillers, and artificial ingredients, focusing solely on delivering the potent nutrients your body needs. By using organic sources, it not only supports your health but also promotes sustainable and environmentally friendly practices.

News – by Matt Jarosy

The Clear Spiral Water Filtration System

You may have noticed something new on our website recently, our Clear Spiral Water Filtration System. After a year of researching various water filtration systems, we decided to release our own. The perfect companion to our additive free formulations. In this post, we break down everything you need to know on our water filtration system. When we were researching water filters, many of them had complex integrations involving plumbing or you needed to wait for gravity to filter the water. We wanted something that was simple to set up, use and maintain whilst providing high quality drinking water. Crafted using high quality stainless steel, our system sits on the countertop next to your kitchen tap where it connects. The system uses two filters, but integrates multiple technologies. Here's all the different filtration technologies we use: Mechanical Purification The most fundamental form of filtration, where the pores in the filter capture and retain any particle larger than 0.05 μm (i.e. bacteria, parasites, graphene oxide, microplastics). Electro-adsorption & Sorption A method for eliminating viruses by taking advantage of the electric charges of the virus proteins to trap them in a filter material with the opposite charges along with physical and chemical attachment of particles. This ensures removal of chloride compounds, biocides and pesticides. Activated Carbon Compressed under very high pressure and heated until it finally hardens into blocks. Removes substances like chlorine, PFAS, BPA and more than 80 other chemical substances. Ion exchange A method by which electric charges in the filter material bind harmful ions such as heavy metals from the water. In combination with the other techniques, radioactive particles such as uranium and cesium- 137 are also captured by the filter. Calcite removal Captures calcite, the mineral that contributes to limescale deposits in pipes and kidney stones, while allowing its less problematic aragonite form to pass through the pores. Bacteriostatic technology In the form of pure silver integrated into the filter matrix, which prevents the growth of bacteria and viruses on the filter. The silver is integrated into the filter material on a microscopic level and cannot dislodge in the water. So what does the filter remove? Integrating multiple technologies into 2 filters allows broad spectrum filtration of many contaminants including: Chlorine (and chlorine derivatives) Disinfectant byproducts (DBPs) Volatile organic compounds (VOCs) Sediment, rust and other debris Polyfluoroalkyl substances (PFAS) Pharmaceutical residues Radioactive particles Pesticides and biocide residues Microplastics Heavy metals Graphene oxide Calcite Viruses Parasites Bacteria Where does this filter technology come from? You will be surprised to learn that the primary filter used in our system actually comes from technology developed to clean up the radioactive site of Chernobyl. The technology, known as multi or micro spiral filtration can remove radioactive particles. However, researchers quickly found that it could also filter many of other things, including the list above. By using this powerful technology in our water filter, we can achieve extremely pure water, but still retain many of the naturally occurring minerals. TPS Glass Bottle We have partnered with Flaska to create our own TPS glass water bottle. TPS stands for Technology of Programming Silicon which involves a vibrational programme consisting of various kinds of information from nature that is imprinted into the silicon dioxide (SiO2) in the glass. This helps improve the water structure. Every order of our water fitration system comes with our 0.75L water bottle, the perfect companion to take your new filtered water on the go. Structured water is a term to describe water in a more coherent state. In this state, water molecules align uniquely, creating a more organized and structured lattice-like pattern.Researchers such as Gerald Pollack refer to this state as the ‘4th Phase of Water’. Some of the properties of this water include a higher viscosity, increased density and a negative charge. The ability of structured water to create a negative charge offers a ready source of electrons that could drive numerous biological reactions. If you want to find out more or purchase our system, click here. References Pollack G. The Fourth Phase of Water: Beyond Solid, Liquid, and Vapor. Ebner & Sons, 2013.Giudice E., & Voeikov V et al. Tedeschi A., Vitiello G. The Origin and the Special Role of Coherent Water in Living Systems. Fields of the Cell, 2015.Sharma A., & Adams C et al. Effect of Health-Promoting Agents on Exclusion-Zone Size. Dose-Response, 2018.

News – by Matt Jarosy

Unveiling the Power of Coenzyme Q10 (CoQ10): A Comprehensive Guide

In the realm of health and wellness, the spotlight often falls on various vitamins and minerals, but one lesser-known yet crucial compound deserves attention – Coenzyme Q10, also known as ubiquinone (because of its ubiquitous presence in organisms). It's chemical name is 2,3-dimethoxy-5-methyl-6-multiprenyl-1,4-benzoquinone (did you try to pronounce that? We hope so). This naturally occurring antioxidant is present in every cell of the human body, playing a vital role in energy production, antioxidant defense, and overall cellular health. Forms of CoQ10 SupplementsSupplemental CoQ10 comes in various forms however the two primary forms available in the market are ubiquinone and ubiquinol.Ubiquinone: This is the oxidized form of CoQ10 and is the more stable of the two and one we use in our formulations. Once ingested, the body converts ubiquinone into ubiquinol, the active antioxidant form. It has demonstrated efficacy in supporting overall health.Ubiquinol: This is the reduced, active form of CoQ10. Ubiquinol is absorbed by the body without the need for conversion but is less stable. This is why we prefer to allow the body to perform the process of oxidation by using ubiquinone. Functions in the Human Body COQ10 it’s not like your everyday mitochondria worker and that's because it's the only component that is not anchored to the inner mitochondrial membrane allowing a certain degree of freedom. It’s also very stable making it a tough antioxidant too (similar structure to vitamin E). It can handle some unstable molecules and rustle them into place with ease. The areas in the body with the highest energy requirements have the highest CoQ10 which makes sense given its role, so for example, the heart and liver.Energy Production: One of the primary functions of CoQ10 is its involvement in the electron transport chain, a critical step in cellular respiration. This process takes place in the mitochondria, where CoQ10 facilitates the production of adenosine triphosphate (ATP), the energy currency of the cell.Cellular Health: CoQ10 plays a crucial role in maintaining the structural integrity of cell membranes, supporting overall cellular health and function. CoQ10 is transported in the bloodstream attached to VLDL and LDL cholesterol, with a plasma half-life of about 30 hours. CoQ10 is very efficient at inhibiting lipid peroxidation in LDL cholesterol.Dietary Sources of CoQ10While CoQ10 is naturally synthesized in the body, it can also be obtained through dietary sources. Foods rich in CoQ10 include:Fish: Salmon, mackerel, and sardines are excellent sources of CoQ10, providing not only this essential compound but also trace minerals.Meat: Organ meats such as liver and kidney contain high concentrations of CoQ10, making them valuable dietary sources.Whole Grains: Whole grains like wheat germ and whole wheat bread contain CoQ10, contributing to its intake through a balanced diet.Fruits and Vegetables: While the levels are lower compared to animal products, fruits like oranges and strawberries, as well as vegetables like broccoli and cauliflower, contribute to overall CoQ10 intake.Benefits of CoQ10 SupplementationCardiovascular Health: CoQ10 is often touted for its cardiovascular benefits. Studies suggest that supplementation may help lower blood pressure, reduce oxidative stress, and improve overall heart function.Anti-Aging Properties: As we age, the body's natural production of CoQ10 declines. Supplementing with CoQ10 has been linked to improved skin health, including reduced wrinkles and enhanced skin hydration.Mitochondrial Support: CoQ10's pivotal role in energy production makes it essential for mitochondrial health. Supplementation may aid in addressing conditions related to mitochondrial dysfunction, promoting overall energy and vitality.Cognitive Function: Some research suggests that CoQ10 supplementation may have neuroprotective effects, potentially slowing cognitive decline and supporting brain health.Exercise Performance: Athletes and fitness enthusiasts often turn to CoQ10 supplements to enhance endurance and reduce exercise-induced muscle damage, though more research is needed in this area. Fertility: COQ10 plays an important role in egg development and sperm health making it a top choice for those wanting to conceive. Why We Need More as We AgeAs we age, the body's ability to produce and utilize CoQ10 diminishes. This decline is particularly pronounced after the age of 30. Several factors contribute to this reduction, including lifestyle factors, medication use, and the natural aging process itself.Medication Interactions: Some medications, such as statins used to lower cholesterol, can deplete CoQ10 levels in the body. Supplementing with CoQ10 is often recommended for individuals on such medications to counteract this depletion.Increased Oxidative Stress: Aging is associated with an increase in oxidative stress, leading to higher levels of free radicals. CoQ10, as a potent antioxidant, becomes even more crucial in neutralizing these free radicals and protecting cells from damage.Decline in Mitochondrial Function: Mitochondrial dysfunction is a hallmark of aging. CoQ10's role in the mitochondria becomes increasingly vital to support cellular energy production and overall cellular health.ConclusionCoenzyme Q10, with its diverse functions and numerous benefits, emerges as a vital player in the maintenance of optimal health. Whether obtained through dietary sources or supplementation, CoQ10 is an invaluable compound that supports cardiovascular health, mitigates the effects of aging, and enhances overall well-being. As our bodies age and face increasing challenges, ensuring an adequate supply of CoQ10 becomes a proactive step towards promoting longevity and vitality. Embracing the power of CoQ10 may be a key to unlocking the secrets of aging gracefully and maintaining robust health throughout the journey of life. Our mitochondrial support complex contains 100mg of COQ10 along with a similar compound known as PQQ. References Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression.Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial. Atherosclerosis. Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials.

News – by Matt Jarosy

Supplements That Help Reduce Histamine: Our New Histamine Metabolism Support Complex

Histamine is a naturally occurring compound in your body, with a pivotal role in various physiological processes. It's a small molecule that plays a significant role in immune responses, stomach acid production, and neurotransmission. While histamine is essential for several bodily functions, an excess of it can lead to a range of uncomfortable symptoms. In this article, we will explore what histamine is, the symptoms of excess histamine, common triggers, and the enzymes responsible for metabolizing histamine. What Is Histamine? Histamine, chemically known as 2-(4-imidazolyl)ethylamine, is a neurotransmitter and a biogenic amine. It is synthesized from the amino acid histidine through a series of enzymatic reactions. Once produced, histamine is stored in specialized cells called mast cells and basophils, primarily in tissues that are in direct contact with the external environment, such as the skin, respiratory tract, and gastrointestinal tract. Symptoms of Excess Histamine Histamine plays a vital role in your immune system, helping to defend your body against pathogens. However, excessive histamine levels can lead to a range of unpleasant symptoms. This condition is known as histamine intolerance, and its symptoms can mimic allergies or other health issues. Common symptoms of excess histamine include Skin Issues: Itching, hives, redness, and eczema are frequent skin reactions to excess histamine. Histamine can cause blood vessels to dilate, leading to these visible skin changes Gastrointestinal Problems: Excess histamine can affect your stomach and intestines, causing symptoms like abdominal pain, bloating, diarrhea, and nausea. Respiratory Symptoms: Histamine can constrict airways and trigger symptoms like sneezing, congestion, and wheezing, which are often associated with allergies Headaches and Migraines: Histamine is a potent vasodilator, meaning it can expand blood vessels in the brain and lead to headaches or migraines. Cardiovascular Symptoms: Some people may experience low blood pressure and an increased heart rate due to histamine-induced blood vessel dilation Fatigue: Histamine intolerance can also lead to fatigue and a general feeling of malaise. Common Triggers of Histamine: Understanding what triggers excess histamine is crucial for managing histamine intolerance. Several factors can contribute to elevated histamine levels in the body. Diet: Certain foods are high in histamine or trigger its release. These include aged cheeses, fermented foods, alcohol, and processed or smoked meats Allergies: Allergic reactions can release large amounts of histamine in response to allergens like pollen, dust mites, or pet dander. Gut Health: An imbalance of gut bacteria can impair the breakdown of histamine in the digestive tract, leading to its accumulation Medications: Some medications, such as non-steroidal anti-inflammatory drugs (NSAIDs) and certain antacids, can interfere with histamine metabolism Stress: Stress can stimulate the release of histamine, exacerbating symptoms in individuals with histamine intolerance. Enzymes that Metabolize Histamine: In your body, histamine levels are carefully regulated by enzymes that break it down and convert it into inactive metabolites. Two key enzymes involved in histamine metabolism are: Diamine Oxidase (DAO): This enzyme is primarily responsible for breaking down histamine in the digestive tract. It's produced by the cells lining your gut and helps prevent histamine from being absorbed into the bloodstream. Histamine N-Methyltransferase (HNMT): HNMT is found in various tissues throughout the body and plays a role in metabolizing histamine in the brain and other organs. It helps regulate histamine levels in the central nervous system. When these enzymes are functioning correctly, they help maintain a balance of histamine in your body. However, genetic factors, medications, or gut health issues can impair the activity of these enzymes, contributing to histamine intolerance. Our new histamine complex uses a variety of ingredients to not only reduce the effects of histamine but also help your body metabolise it more efficiently. Including: Creatine Monohydrate - Enhancing Histamine Metabolism and Energy ProductionCreatine monohydrate indirectly promotes histamine metabolism by supporting the activity of histamine-metabolizing enzymes, such as diamine oxidase (DAO) and histamine-N-methyltransferase (HNMT). By facilitating the breakdown of histamine, creatine reduces its accumulation and helps alleviate histamine intolerance symptoms. Additionally, creatine plays a vital role in cellular energy production, ensuring optimal function and efficiency in histamine metabolism.Organic Acerola: Natural Vitamin C - Antioxidant Defense and Histamine ModulationAcerola is a rich source of natural vitamin C which is a potent antioxidant. Vitamin C protects against histamine-induced oxidative stress, which can exacerbate histamine intolerance symptoms. By neutralizing free radicals and reducing oxidative damage, vitamin C helps maintain a balanced histamine response. Furthermore, vitamin C exhibits anti-inflammatory properties and supports immune function, contributing to a well-regulated histamine system.L-Theanine - Calming Inflammation and Modulating Histamine ReleaseL-theanine, derived from green tea, exerts anti-inflammatory effects by inhibiting the activation of pro-inflammatory signaling molecules, such as nuclear factor-kappa B (NF-κB). By reducing inflammation, L-theanine helps modulate histamine release and mitigate histamine-related discomfort. Moreover, L-theanine promotes relaxation by enhancing alpha brain wave activity, which can reduce stress-induced histamine release. Bromelain - Digestive Support and Histamine BreakdownBromelain, a proteolytic enzyme found in pineapple, aids in the digestion of proteins, including histamine-rich foods. By facilitating protein breakdown, bromelain supports proper digestion and minimizes the absorption of intact histamine molecules. This digestive support helps reduce histamine accumulation in the body and alleviates digestive symptoms associated with histamine intolerance. Bromelain has also been shown to inhibit the production of pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). By reducing inflammation, bromelain may indirectly decrease the release or synthesis of histamine in certain immune cells.Boswellia - Anti-inflammatory Action and Histamine BalanceBoswellia possesses potent anti-inflammatory properties due to its active components, such as boswellic acids. By inhibiting the activity of pro-inflammatory enzymes, including 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2), boswellia helps reduce histamine-induced inflammation and promotes a balanced histamine response. This anti-inflammatory action contributes to overall histamine tolerance and alleviation of associated symptoms.Copper - The Central Atom of Histamine Metabolism EnzymesMinerals play an important role in histamine balance and copper is no exception. Copper is an essential cofactor for DAO, the primary enzyme responsible for breaking down histamine in the gut. Adequate copper levels ensure proper DAO activity, facilitating efficient histamine metabolism and preventing its accumulation.Vitamin B6 - Enzyme Co-Factor in Histamine ClearanceVitamin B6, also known as pyridoxine or P5P, plays a crucial role in the metabolism of histamine. It is a cofactor in the production of enzymes that metabolise histamine, further supporting its regulation. While vitamin B6 may not directly lower histamine levels, its role in histamine metabolism suggests that it can help alleviate the effects of histamine-related conditions, such as allergies or histamine intolerance. Bifidobacterium infantis and Bifidobacterium longum - Gut Microbiota Support for Improved Histamine ToleranceBifidobacterium infantis and Bifidobacterium longum, two beneficial probiotic strains, play a crucial role in supporting a healthy gut microbiota. By promoting a balanced microbial environment, these strains help optimize digestion and reduce histamine production in the gut. Furthermore these two specific strains have been to suppress allergic type symptoms and decrease histamine levels. Find out more here

News – by Matt Jarosy

Which Form of Magnesium Should I Take? Magnesium Bisglycinate, Magnesium Taurate & Magnesium Malate

Magnesium is an essential mineral that plays a crucial role in many biological processes, including energy production, protein synthesis, and nerve function. However, many people do not get enough magnesium in their diets, and as a result, magnesium deficiency is a common problem worldwide; some estimates suggest that up to 50% of the population may not be getting enough magnesium in their diets. Fortunately, magnesium supplements can help to fill the gaps but with so many different forms of magnesium it can be difficult to know which one to choose. In this article, we will discuss the differences between our three popular forms of magnesium supplements: magnesium malate, taurate, and glycinate. First, let's talk about what a magnesium chelate is. A chelate is a molecule that binds to a metal ion, in this case, magnesium, to form a stable complex. Chelated magnesium supplements are designed to enhance absorption and bioavailability, meaning the body can more easily absorb and utilize the magnesium. There are many different types of magnesium chelates, but malate, taurate, and glycinate are among the most popular.Magnesium malate is a chelated form of magnesium that is bound to malic acid. Malic acid is a natural compound found in many fruits and vegetables, and it plays a role in the production of energy in the body. Magnesium malate is often used to help support energy production, as well as to promote muscle relaxation and reduce muscle pain and stiffness. It is also thought to be beneficial for people with fibromyalgia, a condition characterized by widespread muscle pain and fatigue. Magnesium malate is generally well-tolerated and does not usually cause digestive upset.Magnesium taurate is a chelated form of magnesium that is bound to taurine, an amino acid that is found in many foods, including meat and fish. Taurine is known for its ability to support cardiovascular health and improve exercise performance, and it may also help regulate blood sugar levels. Magnesium taurate is often used to help support healthy heart function and improve exercise endurance. It is also thought to be helpful for people with anxiety or depression, as taurine has been shown to have calming and mood-stabilizing effects. Magnesium taurate is generally well-tolerated and does not usually cause digestive upset.Magnesium glycinate is a chelated form of magnesium that is bound to glycine, an amino acid that is found in many high-protein foods, including meat, fish, and dairy. Glycine is known for its ability to promote relaxation and improve sleep quality, and it may also help support healthy brain function. Magnesium glycinate is often used to help support healthy sleep patterns and reduce symptoms of anxiety and stress. It is also thought to be beneficial for people with digestive issues, as glycine has been shown to help repair the lining of the digestive tract. Magnesium glycinate is generally well-tolerated and does not usually cause digestive upset.So, which form of magnesium is best for you? The answer depends on your individual needs and health goals. If you are looking to support energy production and reduce muscle pain and stiffness, magnesium malate may be the best choice for you. If you are looking to support cardiovascular health and improve exercise performance, magnesium taurate may be the best choice for you. If you are looking to promote relaxation, improve sleep quality, and reduce symptoms of anxiety and stress, magnesium glycinate may be the best choice for you. However, it is important to note that all three forms of magnesium have some degree of overlap in their benefits, and any of them may be helpful for general magnesium supplementation.It is important to note that while magnesium supplements are generally safe and well-tolerated, taking too much magnesium can cause digestive upset. Therefore, it is important to follow the recommended dosage guidelines on the supplement label and to consult with a healthcare provider before starting any new supplement regimen.Finally, let's briefly discuss some symptoms of magnesium deficiency. Magnesium deficiency is a common problem, and it can cause a wide range of symptoms, including muscle cramps, fatigue, irritability, anxiety, and irregular heartbeat. In more severe cases, magnesium deficiency can lead to conditions such as osteoporosis, hypertension, and diabetes.In conclusion, magnesium is an essential mineral that plays a critical role in many biological processes, and magnesium supplements can be a helpful way to ensure that you are getting enough magnesium in your diet. Choosing the right form of magnesium for you depends on your individual needs and health goals. You can find out full range of magnesium blends here. References Magnesium in Prevention and Therapy - https://pubmed.ncbi.nlm.nih.gov/26404370/. The Role of Magnesium in Neurological - Disorders: https://pubmed.ncbi.nlm.nih.gov/31284519/ Magnesium and Depression: A Systematic Review - https://pubmed.ncbi.nlm.nih.gov/29996882/ Magnesium in Hypertension, Cardiovascular Disease, Metabolic Syndrome, and Other Conditions: A Review - https://pubmed.ncbi.nlm.nih.gov/31594303/ Magnesium and Sleep: A Systematic Review of Human Trials - https://pubmed.ncbi.nlm.nih.gov/28675917/

News – by Matt Jarosy

Pyrroloquinoline quinone: From Stardust to Mitochondria

We've recently launched our mitochondrial support supplement which contains a compound known as Pyrroloquinoline quinone, otherwise known as PQQ. In this post we wanted to dive into what this compound is and its functions. PQQ is a small molecule that is found in plants, bacteria, and some animal tissues. It has a chemical structure similar to that of vitamins and is classified as a redox cofactor, which means that it can participate in chemical reactions that involve the transfer of electrons. PQQ has gained attention in recent years due to its potential health benefits, including its ability to act as an antioxidant and support cognitive function. Recent evidence suggests that compounds like PQQ are components of interstellar dust, considered precursors to organic life. One of the primary functions of PQQ is its ability to act as an antioxidant. Antioxidants are substances that can neutralize harmful molecules called free radicals, which can cause damage to cells and contribute to the development of diseases such as cancer and heart disease. PQQ has been shown to be a potent antioxidant, with the ability to scavenge free radicals and prevent their damaging effects. It has also been shown to stimulate the production of other antioxidants in the body, including superoxide dismutase (SOD) and glutathione. PQQ has also been shown to modulate the expression of certain genes that are involved in energy metabolism and mitochondrial function. In particular, PQQ has been shown to increase the expression of genes that are involved in the production of mitochondria and the transport of proteins into mitochondria, which may help to improve their function. PQQ has also been studied for its potential cognitive benefits. Some research has suggested that PQQ may support cognitive function by protecting neurons, or brain cells, from oxidative stress. It has also been shown to promote the growth and survival of neurons, which may help to improve brain function.In addition to its potential cognitive benefits, PQQ has also been studied for its effects on energy metabolism and mitochondrial function. Mitochondria are the powerhouses of cells, responsible for producing the energy from oxidative phosphorylation that cells need to function. PQQ has been shown to improve the function of mitochondria and increase the production of energy in cells. This may have a variety of potential health benefits, including improving physical performance and reducing fatigue. There is also some evidence to suggest that PQQ may have anti-inflammatory effects. Inflammation is a normal response to injury or infection, but chronic inflammation has been linked to a number of diseases, including heart disease, diabetes, and cancer. PQQ has been shown to reduce inflammation in animal studies, and there is some evidence to suggest that it may have similar effects in humans. PQQ is found naturally in small amounts in a variety of foods, including kiwifruit and peppers. Although the body can produce small amounts of PQQ, more may be needed in times of oxidative stress. In this situation additional PQQ may be able to help balance redox status so that we can make energy efficiently. The available evidence suggests that PQQ may have a variety of potential benefits for human health, including its ability to act as an antioxidant, support cognitive function, improve energy metabolism and mitochondrial function, and reduce inflammation. As with any supplement, it is important to speak with a healthcare provider before starting to use PQQ, especially if you have any existing health conditions or are taking any medications. References Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects

News – by Matt Jarosy

Fueling Your Mitochondria: Make More Energy

Mitochondria are membranous, slightly elongated structures contained within the cytoplasm of almost all eukaryotic cells. Using aerobic respiration, they take oxygen and the compounds in our food to make energy (in the form adenosine triphosphate, known as 'ATP'). Each cell contains the appropriate amount of mitochondria relative to its energy use. That means organs such as the heart contain a lot of mitchondria, infact each cell of your heart contains around 5000 mitochondria. When we lose mitochondria or they begin to malfunction, it can increase our risk of 'dis-ease'. It is thought that mitochondria were originally independent bacterial entities which at some point over a billion years ago (through much trial and error) entered other bacterial cells and decided to partner up. This moment was monumentous, you could argue this was the beginning of complex life as we know it. Two important cycles that occur within the mitochondria for energy production are the the tricarboxylic acid cycle (TCA) and the electron transport chain (ECT). Think of these like factory lines, they need to be flowing freely in order for energy to be generated efficiently. During normal oxidative phosphrlation (whereby ATP is formed by electron transfer) about 2 percent of the oxygen consumed is converted to superoxide (a type of free radical). This is where nutrition comes, anti-oxidants from our diet help to mop up the free radicals formed by energy production. Unfortunately, making energy comes with exhaust. So what do mitochondria need to function properly? Magnesium: In order for ATP be 'activated', it needs to form a complex with magnesium. B Vitamins: These are like the workers on the factory line, helping to pass energy from one cycle to another. Each B vitamin has a specific role, for example riboflavin (B2) plays a key role in shuttling electrons from the TCA and cobalamin (B12) is needed to generate s-adenosyl methionine (SAMe) which is part of the protein sub unit that makes up the ECT. COQ10: You can think of COQ10 as the oil in the factory, it helps to keep things running smoothly. It can regenerate free radicals and soothe them back into the ECT. PQQ: Otherwise known as pyrroloquinoline quinone, helps control redox processes in the mitochondrial, essentially balancing oxidative stress as well as stimulating energy production. B3: We need B3 or niacinamide to manufacture NADH (energy carrier) and to supply protons for oxidative phosphorylation. Copper: Copper is a cofactor in the ECT so that ATP can be released, it also plays a key role in mitochondrial signaling and mitophagy. Given mitochondria's role in the body, mitocondrial may be the key to unlocking the process of aging itself. According to this theory, with age, mitochondria accumulate ROS-induced damage and become dysfunctional. With time, the function of cells declines causing aging and subsequent death. Many things can induce oxidative stress in humans, including not having the necessary cofactors for making energy. Remember, making energy makes exhuast. The more we can buffer this exhaust, the better.

News – by Matt Jarosy

The Power of Vitamin C in Human Health

With the launch of our latest organic wholefood vitamin C formulation, we wanted a dive a bit more into the benefits of wholefood vitamin C and why it should be a regular part of your diet. Vitamin C is one of the most well-known and widely studied vitamins out there. It was first discovered in the 18th century and since then, we've learned a lot about its many functions in the body. It's been shown to help support a healthy immune system, skin health, and even cognitive function. Here's a list of all specific functions of vitamin C Required for synthesis of collagen fibers through hydroxylation of proline and lysine. Nourishes the adrenal glands by supporting healthy steroid hormone production. Enhances chemotaxis, phagocytosis, and ultimately microbial killing as part of the immune response. Enhances differentiation and proliferation of B and T-cells, important immune regulatory cells. Activation of the B vitamin folic acid and the conversion of cholesterol to bile acids which are needed for digestion. Conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. Helps balance LDL & HDL cholesterol. But what many people don't know is that not all vitamin C is created equal. Whilest you can find synthetic vitamin C in many supplements derived from processed corn, wholefood vitamin C contain all of the nutrients and fiber that nature intended. So why choose wholefood vitamin C? Wholefoods tend to be more bioavailable than synthetic nutrients. This means that your body can more easily absorb and use the nutrient. Additionally, wholefood vitamin C contains other important nutrients like flavonoids and phytochemicals that work together to provide even more health benefits. It also contains tyrosinase, a copper containing enzyme used in melanin which gives our skin its color. So why do regular vitamin C supplements have such high dosages? This is due to the fact that these vitamins are not bound to other nutrients and fiber like they are in wholefoods. It's important to note that just because there's a higher dosage, it doesn't mean you will absorb it all. In fact, most people only absorb about 20-30% of the synthetic vitamin C they take in supplement form. When you take wholefood vitamin C, your body is able to utilise all the components as nature intended. If you're looking for a way to increase your intake of vitamin C, our new organic wholefood vitamin C supplement is a great option. It's made with freeze dried acerola cherries, camu camu berries & peppermint- all of which are rich sources of vitamin C. Plus, it's certified organic, non-GMO, and vegan. Organic certification means that the ingredients are grown without the use of synthetic pesticides, herbicides, or fertilizers. Non-GMO means that the ingredients have not been genetically modified in any way. Now you might be wondering why peppermint? For some people, wholefood vitamin C can cause a histamine reaction (even though vitamin C is a natural antihistamine) so we added a pinch of peppermint to our formulation to help reduce the histamine load. Peppermint also has other benefits like supporting digestion and providing a boost of energy. Whats the best way to take vitamin C? If it's your first time trying this supplement, we would always suggest trying 1 capsule after food first. This allows your body time to get used to the supplement and helps reduce any potential digestive discomfort. Once you have tried it this way feel free to increase the dosage to 3 capsules or as professionally directed. We like to take our wholefood vitamin C away from food for optimum absorption. References https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098779/?ref=E_pvv9KrdcFc94 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296744/?ref=E_pvv9KrdcFc94 https://pubmed.ncbi.nlm.nih.gov/29763052/

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Why Choose Organic Ingredients?

All our wholefood range is certified organic by the Soil Association. The Soil Association symbol is a recognised and trusted mark of organic certification internationally but why choose organic? Rather than relying on chemical inputs, organic farmers and growers adopt management practices that build and enhance natural soil fertility with the application of organic matter, green manures and long-term crop rotations, and controlling weeds, pests and diseases through mechanical weeding, variety choice and by encouraging natural predators. A growing number of studies are now linking pesticides to various human health effects. A 2004 review co-authored by the National Cancer Institute concluded that “epidemiological evidence clearly suggests that at current exposures pesticides adversely affect human health”. Some pesticides are also known to disrupt endocrine or hormone function, research reviewed by the EPA and published in a toxicology handbook states. A 2013 report commissioned by the European Food Safety Authority reviewed 600 research studies on pesticides and found the strongest associations with certain cancers, asthma, childhood leukemia and Parkinson’s disease. But it's not just human health, organic farms have up to 50% more wildlife abundance on average. By supporting organic farming practices, you help support both the environment and your health. You can find our certified organic range here. References https://www.soilassociation.org/take-action/organic-living/why-organic/better-for-wildlife/ https://www.annualreviews.org/doi/full/10.1146/annurev.publhealth.25.101802.123020#_i34 https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2017.5007

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Everything You Need To Know On Magnesium Glycinate

Magnesium glycinate (or bisglycinate) is a highly bioavailable form of magnesium made by chelating magnesium to the amino acid glycine. Chelated magnesium is a unique preparation method that offers increased stability, better bioavailability, and less chance of impacting the digestive tract. Magnesium glycinate is thought to be one of the most relaxing forms of magnesium, partly because of what it is chelated to, in this case glycine. Glycine (also known as 2-Aminoacetic Acid) is an amino acid and a neurotransmitter. It has a broad range of roles in the body, from regulating blood sugar to faciliating the production DNA and RNA. It is also one of three amino acids that your body uses to make glutathione, a powerful antioxidant that helps protect your cells against oxidative damage caused by free radicals. Although glycine can be both excitatory and inhibitory, many people find it relaxing on the nervous system. Studies show that higher levels of this amino acid may, help you fall asleep more quickly, reduce symptoms of insomnia and promote deeper more restful sleep. Which magnesium to use We recommend people try different forms of magnesium to see which form they prefer. Some of our customers like to take magnesium malate in the morning and magnesium glycinate in the evening. It's important to listen to your body and find the form and dose that works for you.

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How Stress Affects Your Magnesium Levels

One of the questions we get asked is do we neeed more magnesium if we’re stressed? To answer that question, we have to consider how stress works. Stress has a profound effect on the body. The sympathetic nervous system response drives the body into fight and flight at the expense of many other bodily processes. Calcium shuttles into our muscles for contraction and cortisol streams round our body along with adrenaline. Energy stores become liberated and glucose becomes instantly available for our body to burn. This is an amazing response which has allowed our species to survive. If we didn't have cortisol, we wouldn't be able to wake up in the morning. However, this stress response is also very demanding on the body. Stress is a very energy intensive process and magnesium is the major cofactor for energy production. The very energy currency of the body ATP, must always be complexed with magnesium to be active. It's important to remember that magnesium is the fourth most abundant cation in the body and the second most abundant intracellular cation. This means that the majority of magnesium is found within our cells. Cells are where the action is and where most of our energy is required. This is one of the reasons why magnesium status is interversely associated with stress levels, that is to say as stress goes up, magnesium goes down. Both stress and hypomagnesemia potentiate each other’s negative effects. Indeed, hypomagnesemia has been associated with stressful conditions such as photosensitive headaches, fibromyalgia and chronic fatigue. Acute stress has been shown to be associated with increased plasma magnesium levels and increased urinary magnesium excretion which highlights how magnesium responds to stress. Sometimes it can be hard to step back and think about how much stress we experience in a given day. Stress can be physical, such as from exercise, or mental, such as from work or personal relationships. Stressful events, both major and minor, can also take a toll on our magnesium levels. Take a minute to think about all the stressors in your day. You can increase your magnesium through various foods such as fruits, dark chocolate, leafy green vegetables, nuts and seeds (don't forget to soak them!), brown rice and avocados amongst others. You can also get magnesium from water in the form of magnesium chloride or magnesium bicarbonate but typically you will have to make this yourself as most tap water contains very little magnesium. One of the most gentle ways to increase magnesium is to have a bath with magnesium flakes. This is because magnesium can absorbed transdermally, through the skin. When you have a bath with magnesium chloride flakes, you are essentially giving yourself an IV push of magnesium because it's readily absorbed. Baths are also great for relaxation which has a knock-on effect of helping to reduce stress. In terms of supplements, take a look at our magnesium blends here. Each capsule provides 100mg of magnesium per capsule. Don't be fooled by other manufacturers stating 1500mg servings in supplements, they are listing the total weight of the compound (including what the magnesium is chelated too) and not the actual magnesium that is usable. Our magnesium products is also vegan, non-GMO and free from gluten, soya, dairy, artificial colours and flavours. We would recommend trying different forms of magnesium to which one works for you. If you want to learn more about the different forms of magnesium, checkout our comprehensive guide here. References https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316205/?ref=ZwOb90Mpn4WO https://pubmed.ncbi.nlm.nih.gov/29920004/

News – by Matt Jarosy

What Is Iodine? The Halogen Inside Each Of Your Cells

In conjuction with the release of our latest supplement, we wanted to talk a little bit more about Iodine. Our new organic seaweed blend contains 346ug of wholefood iodine which equates to 230% of the RNI (reference nutrient intake), but why do we need it? and what really is iodine? Bernard courtois was the man who first discovered iodine which is a halogen if you're looking at the periodic table. He was originally making gunpowder from potassium and sodium but accidentally added too much sulphuric acid to seaweed ash and observed a distinct purple colour. This was the birth of iodine ('iodes' in greek means violet-coloured). There are naturally occurring non-radioactive and radioactive iodine forms. Radioactive iodine has uses in medicine to diagnose and treat certain conditions whereas natural forms come in many sources like seaweed. In human health iodine is often misunderstood. It is a micronutrient that is found in each of your cells but is a relatively rare earth element ranking 62. It is typically concentrated in sea organisms such as seaweed which means the further inland you go, the further you get away from iodine and the more prevalent iodine deficiency becomes. This is highlighted by what was known as 'the goilter belt' (areas within Great Lakes, Appalachian, and Northwestern U.S. regions etc) which had high prevalences of iodine deficiency. Goiter is an enlarged thyroid gland; when a gland doesn’t get what it needs, it typically increases its surface area in an attempt to find more of its missing micronutrient, in this case iodine. In order to combat the epidemic of goiter happening worldwide governments began adding iodine to salt products (iodized salt) and although this did have an impact on the prevalence of goiter, it did not address the wider issues. Between 1970s - 2000 studies by NHANES still showed a 50% drop in iodine levels across the US (similar figures in many parts of europe) with the percentage of pregnant women with low iodine concentrations increasing 690% over this time period. The question is, why was this? This was likely due to a couple of different reasons including reduced dietary intake and exposure to other halides such as bromide and flouride. Specific functions of iodine Iodine is an essential ingredient for thyroid hormones thyroxine (T4) and triiodothyronine (T3) which are key hormones in the regulation of your metabolic rate. Every single cell in your body depends on adequate levels of thyroid hormone. Deficiencies or overdoses of iodine are risk factors in hypothyroidism and autoimmune diseases like Graves and Hashimotos. Iodine is not found in large quantities in the body although there’s around 15-20mg in the thyroid of an average adult. The thyroid gland concentrates it there using a system known as the sodium/iodide symporter (NIS) of which the mammary glands have the same mechanism for concentrating iodine. But it's not just the thyroid gland, iodine might just be one of, if not the most important micronutrient for breast health. There is a wealth of research showing the connection between iodine deficiency and breast cancer. As mentioned, the breasts also have a sodium/iodide transport system, concentrating iodine there. The concentration of iodine in mammary glands and its secretion here highlights the importance of iodine. Low levels conclusively cause changes to the structure and function of the breasts. It’s worth noting that in animal studies, iodide is ineffective at reversing pre-cancerous lesions of breast tissue whereas iodine is much more effective. Iodine also helps prevent lipoperoxidation (the oxidation of lipids) which has been found to be elevated in breast tumours and can help balance estrogen by maintaining the estrogen/estriol ratio. When there is an imbalance in estrogen ratios (estrone, estriol and estrogen), women can suffer from things like fibrocystic breasts, a condition where breasts have cysts which are usually painful to touch. In cancer, iodine has the ability to induce apoptosis, the process of timed cell death which is essential for the regulation of cancer in the body. It does this through a few mechanisms like the iodination of lipids. It really does pack a punch in the anti-oxidant department. Why we might need more iodine now One of the issues around halogens is that they like to compete in the body. Other halides, particularly bromide and fluoride can bind to iodine receptors in the body, blocking absorption. Bromide has no place in the body. It is a toxic compound which is used as a flame retardant in many furnishings and in baked goods as a dough conditioner. Fluoride is also added to many water supplies to help strengthen teeth but it comes at a cost. Furthermore, perchlorate, another halogen which contains one atom of chlorine and four atoms of oxygen, further displaces iodine. Perchlorate has contaminated many water supplies due to poor disposal. It is used in a variety of products like air bags, leather tanning, fireworks and in rocket fuel. The introduction of these compounds, on top of low dietary intake is a recipe for deficiencies. This is one of the reasons why some scientists believe the RNI is inadequate.

The different types of magnesium in health

News – by Matt Jarosy

The Different Forms of Magnesium: Your Comprehensive Guide

Do you often feel run down and stressed? Are you having trouble sleeping at night? If so, you might be a little low on magnesium. Magnesium is a mineral that is essential for human health, and it plays a role in many important bodily functions. Unfortunately, many people are not getting enough magnesium in their diets. In this blog post, we will discuss the different forms of magnesium and their individual benefits. One of the more confusing aspects of magnesium supplements is that manufacturers will often advertise the total weight of the product as magnesium. For example, let's take a 500mg capsule of magnesium glycinate. Not all of this is pure magnesium, the majority of the product is actually what it is bound to, in this case glycine. Only a small percentage is usable magnesium. This is because magnesium needs to be bound to something to be absorbed by the body, otherwise it would get broken down quickly in your stomach acid before it can be absorbed. Here at ELIVIDE, we always list the net magnesium on our supplements so you know exactly how much magnesium you are getting. So without furtheado, what are the different types of magnesium? Magnesium oxide: This form of magnesium is the most common and it is also the cheapest. It is made by combining magnesium and oxide. It has a high amount of magnesium but It is not very well absorbed by the body as it is an inorganic chelate. Inorganic chelates are not as easily absorbed by the body compared to organic chelates. Magnesium carbonate is another inorganic form of magnesium. Magnesium citrate: This form of magnesium is more expensive than magnesium oxide and it is better absorbed by your body. However, magnesium citrate tends to have the most laxative effect. Magnesium citrate is magnesium bound to citric acid, however too much citric acid can interfere with copper metabolism so we would suggest avoiding this form. Magnesium chloride: This form of magnesium is often used in liquid forms of magnesium such as a mineral drops, made by combing magnesium and chloride. This can be a gentle way to introduce yourself to magnesium and it has a relatively high bioavailability. Magnesium glycinate: This form of magnesium is considered one of the most gentle forms of magnesium made by combining magnesium to the amino acid glycine. Glycine tends to be relaxing on its own so magnesium glycinate can be a great option for sleep. Magnesium glycinate has a high bioavability due to the protection of the glycine. Find out more about our magnesium glycinate here. Magnesium malate: This form of magnesium is made by combining magnesium to malic acid. Malate is a compound that is naturally found in fruits and it can increase energy production in cells. This makes magnesium malate a great option for people with fatigue but many people find it helps them sleep too. Find out more about our magnesium malate here. Magnesium orotate: This form of magnesium is made by combining magnesium to orotic acid. Orotic acid is a nucleotide that is naturally found in the body and it helps with magnesium absorption. This form of magnesium is sometimes used by athletes as it can help with energy production. Magnesium threonate: Threonate is a relatively new form of magnesium and it is made by combining magnesium to L-threonate. This form of magnesium is thought to cross the blood brain barrier more effectively which means it may be helpful for cognitive function, however its important to note that all magnesium crosses the blood brain barrier. Magnesium sulphate: You might know this one from Epsom salt, this form of magnesium is made by combining sulphur and magnesium. It is often used in baths as it can be absorbed through the skin. So which form of magnesium should you take? We would recommend trying different forms of magnesium to find the form that works for you. If you're just starting out with magnesium, trandermal magnesium can be gentle way to introduce your body to this important mineral. It's important to note that magnesium is a key electrolyte alongside potassium, sodium and calcium. If you increase magnesium, don't forget to increase your other elecolytes too. This way you won't upset the delicate balance of elecrolytes in the body.

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Real Vitamin C vs Ascorbic Acid

Since human's chemically isolated vitamin C (ascorbic acid), it has been one of the most widely used compounds on the planet. Vitamin C used to be derived naturally from rose hips but we soon discovered a more cost effective way of developing this vitamin which involved the use of corn. To create a concentrated form of vitamin C using corn takes a lot more processing than you might think. Melanie Werner describes the production of ascorbic acid in her book about the food industry. 'It starts not with corn kernels or even corn starch but with sorbitol, a sugar alcohol found naturally in fruit and made commercially by cleaving apart and rearranging corn molecules with enzymes and a hydrogenation process. Once you have sorbitol, fermentation starts, a process that tends to muck up surrounding air less than chemical synthesis (although it's been known to cause problems with water pollution). The fermentation is done with bacteria, which enable more molecular arrangement, turning sorbitol into sorbose. Then another fermentation step, this one usually with a genetically modified bacteria, turns sorbose into something called 2-ketogluconic acid. After that, 2-ketogluconic acid is treated with hydrochloric acid to form crude ascorbic acid. Once this is filtered, it is purified and milled into a fine white powder. It is then ready to be shipped off as finished ascorbic acid, mixed with other nutrients and added to your corn flakes'. The question is, does our body recognise this synthetic, albeit 'chemically correct' form of vitamin C the same as what we find in nature? It is easy to associate chemical names of vitamins (like ascorbic acid) with the vitamin as a whole but the reality is usually very different. Vitamins are more than just chemical structures, in nature they are found with a variety of cofactors like bioflavonoids that aid assimilation. One of the problems with taking synthetic ascorbic acid, or indeed ascorbate forms of minerals is that they inhibit a key enzyme in the body known as ferroxidase. The activity of ferroxidase plays a key role in our iron regulation and therefore taking anything that inhibits this pathway may contribute to iron dysregulation in the body. We believe that vitamin C should always be in its wholefood form as nature intended. Next week we have our natural vitamin C supplement launching, derived solely from organic camu camu berries. These berries contain one of the highest concentrations of vitamin C on the planet and really pack a punch in the antioxidant department. References https://pubmed.ncbi.nlm.nih.gov/1717196/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296744/

News – by Matt Jarosy

The Implications of Low Magnesium On The Body

We’ve all seen the posts about how important magnesium is, it needs no introduction. A mineral essential to combat stress. We know that it’s involved in hundreds of enzymes but what really are the implications of long term low magnesium intake? How does it manifest in the body? In this post, we will explore how it impacts key systems. Cardiovascular system The heart needs a constant source of energy to keep its electrical activity going and that means magnesium. Magnesium is intimately related to calcium, the latter allowing contraction and magnesium allowing relaxation. When there’s low magnesium, calcium can become deregulated which increases chance of deposits in the arteries. As calcium levels rise, arterial vasospasms and constriction increase which raises blood pressure. Deficiency of magnesium can significantly reduce the membrane potential polarisation through sodium and calcium accumulation. This means low magnesium is linked to things like arrhythmias. Inflammation & immune response Low magnesium means glutathione (a major antioxidant) production becomes impaired which in turn promotes calcium accumulation. Furthermore, inflammatory cytokines (proteins involved in immune response) and interleukins become raised whic promote an inflammatory response and damage to the endothelial wall. Immune cells will not be able to function optimally without adequate magnesium, for example against viruses and subsequently this increases activation of Epstein Barr (EBV). Conversion pathways Low magnesium means key conversions in the body become impaired. One of these includes vitamin or hormone D. Vitamin D will not be able to cycle between its binding sites from inactive to active without sufficient magnesium. As vitamin D is an acute phase reaction in its storage form, that means the body will not be able to switch on its conversion during high stress situations such as during infection. Liver detoxification The liver consumes an incredible amount of energy (ATP). Low magnesium reduces the liver's ability to conjugate toxins and excrete them through ATP synthase impairment. Low magnesium is almost always found in non-alcohol liver disease. Magnesium protects against bile duct ligation-induced liver injury. References https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783146/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852744/ https://pubmed.ncbi.nlm.nih.gov/24896250/ https://pubmed.ncbi.nlm.nih.gov/31807559/ https://pubmed.ncbi.nlm.nih.gov/25048990/ https://pubmed.ncbi.nlm.nih.gov/29480918/

News – by Matt Jarosy

The Many Functions of Taurine, a Sulphur Containing Amino Acid

Have you ever heard of taurine before? Like many people, you may not be familiar with this compound. Taurine is an amino sulfonic acid, but it is often referred to as an amino acid. It is found in the tissues of all animals, including humans. In fact, taurine is the most abundant free amino acid in the human body. It is highest in the brain and heart, followed by the muscles. Taurine is also found in breast milk. Unlike many other amino acids, taurine is not used to build new tissues. Instead, it's considered a conditionally essential amino acid, meaning it becomes essential only in times of illness and stress. You can synthesise taurine from cysteine and methionine, but the process is very inefficient. Taurine is only found in animal sources such as eggs, beef, turkey & shellfish. If you are following a plant based diet, you might find yourself deficient in this sulphur containing amino acid. Now you might be thinking, isn't taurine adding to energy drinks? The reason taurine is sometimes added here is because it can improve mental focus and physical performance. And don't worry, taurine isn't from bull urine as many people think, although the name 'taurine' comes from the latin word for bull or ox, 'taurus'. Taurine has a number of important functions in the body. It helps to regulate heartbeat, muscle contraction, and cell volume. It also plays a role in calcium signalling, which is important for proper nerve and brain function along with magnesium utilisation. Here's a list of more specific functions: Aiding magnesium utilisation Liver copper metabolism Retinol absorption Supports healthy estrogen detoxification Cholesterol control Maintaining proper hydration and electrolyte balance in your cells Forming bile salts (which play an important role in digestion) Central nervous system neuromodulation Regulating calcium binding and transport Insulin sensitivity Protecting mitochondria from reactive oxygen species Taurine is often taken before bed due to its central nervous system neuromodulation. It faciliatates GABA receptors which is a neurotransmitter that has a calming effect on the brain and nervous system whilst reducing the negative effects of glutamate (which is excitatory). Taurine may promote deeper sleep because of this. That being said, many people like to take taurine in the morning to help start their day. Our magnesium taurate supplement contains around 400mg of taurine, however many people take more, especially athletes or people who are highly active. If you do take more, we recommend keeping it under 3000mg a day. While taurine has a number of benefits, there are also some potential side effects to be aware of. When taken in large doses, taurine can cause dizziness and upset stomach but this is likely only to occur in the very high dosages. It can also interact with some medications, so if you are taking any be sure to speak with a healthcare professional before adding taurine to your diet. References Review: taurine: a "very essential" amino acid Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview The Role of Taurine in Mitochondria Health: More Than Just an Antioxidant

News – by Matt Jarosy

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