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ELIVIDE Wellness Journal

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Fueling Your Mitochondria: Make More Energy

by Matt Jarosy

Fueling Your Mitochondria: Make More Energy

Mitochondria are membranous, slightly elongated structures contained within the cytoplasm of almost all eukaryotic cells. Using aerobic respiration, they take oxygen and the compounds in our food to make energy (in the form adenosine triphosphate, known as 'ATP'). Each cell contains the appropriate amount of mitochondria relative to its energy use. That means organs such as the heart contain a lot of mitchondria, infact each cell of your heart contains around 5000 mitochondria. When we lose mitochondria or they begin to malfunction, it can increase our risk of 'dis-ease'. It is thought that mitochondria were originally independent bacterial entities which at some point over a billion years ago (through much trial and error) entered other bacterial cells and decided to partner up. This moment was monumentous, you could argue this was the beginning of complex life as we know it. Two important cycles that occur within the mitochondria for energy production are the the tricarboxylic acid cycle (TCA) and the electron transport chain (ECT). Think of these like factory lines, they need to be flowing freely in order for energy to be generated efficiently. During normal oxidative phosphrlation (whereby ATP is formed by electron transfer) about 2 percent of the oxygen consumed is converted to superoxide (a type of free radical). This is where nutrition comes, anti-oxidants from our diet help to mop up the free radicals formed by energy production. Unfortunately, making energy comes with exhaust.  So what do mitochondria need to function properly? Magnesium: In order for ATP be 'activated', it needs to form a complex with magnesium.  B Vitamins: These are like the workers on the factory line, helping to pass energy from one cycle to another. Each B vitamin has a specific role, for example riboflavin (B2) plays a key role in shuttling electrons from the TCA and cobalamin (B12) is needed to generate s-adenosyl methionine (SAMe) which is part of the protein sub unit that makes up the ECT. COQ10: You can think of COQ10 as the oil in the factory, it helps to keep things running smoothly. It can regenerate free radicals and soothe them back into the ECT. PQQ: Otherwise known as pyrroloquinoline quinone, helps control redox processes in the mitochondrial, essentially balancing oxidative stress as well as stimulating energy production. B3: We need B3 or niacinamide to manufacture NADH (energy carrier) and to supply protons for oxidative phosphorylation. Copper: Copper is a cofactor in the ECT so that ATP can be released, it also plays a key role in mitochondrial signaling and mitophagy. Given mitochondria's role in the body, mitocondrial may be the key to unlocking the process of aging itself. According to this theory, with age, mitochondria accumulate ROS-induced damage and become dysfunctional. With time, the function of cells declines causing aging and subsequent death. Many things can induce oxidative stress in humans, including not having the necessary cofactors for making energy. Remember, making energy makes exhuast. The more we can buffer this exhaust, the better.

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PQQ, COQ10 and mitochondria

by Matt Jarosy

Pyrroloquinoline quinone (PQQ): From Stardust to Mitochondria

We recently launched our mitochondrial support supplement, Metabolic Flow, which contains a unique compound called Pyrroloquinoline Quinone (PQQ). In this article, we’ll explore what PQQ is, how it works, and why it’s such an intriguing nutrient for cellular energy, brain function and overall vitality. What is PQQ? PQQ is a naturally occurring molecule found in plants, bacteria and some animal tissues. Structurally similar to a vitamin, it functions as a redox cofactor – meaning it assists in chemical reactions involving electron transfer. These reactions are essential for generating energy and protecting cells from oxidative damage. Interestingly, scientists have even detected PQQ-like compounds in interstellar dust, suggesting it may have played a role in the origins of organic life. In the human body, PQQ acts as a potent antioxidant and supports key pathways involved in mitochondrial function and cellular renewal. It’s one of the few compounds known to stimulate the growth of new mitochondria in cells, a process known as mitochondrial biogenesis. The Role of PQQ as an Antioxidant Antioxidants protect the body from free radicals – unstable molecules that damage DNA, proteins and cell membranes. PQQ is particularly effective because it can repeatedly cycle between oxidised and reduced forms, allowing it to neutralise free radicals multiple times before breaking down. Studies show that PQQ not only scavenges free radicals directly but also enhances the body’s own antioxidant defences by stimulating the production of superoxide dismutase (SOD) and glutathione. These compounds help maintain cellular integrity and protect against oxidative stress, which contributes to premature ageing, inflammation and chronic disease. PQQ and Mitochondrial Function Mitochondria are the powerhouses of our cells, responsible for generating adenosine triphosphate (ATP) through oxidative phosphorylation. Healthy mitochondrial function underpins every aspect of physical and mental performance, from muscle endurance to cognitive focus. PQQ supports mitochondria in two main ways. First, it helps existing mitochondria operate more efficiently by improving the transport of proteins involved in energy metabolism. Second, it stimulates the creation of new mitochondria by activating genes such as PGC-1α and Nrf1, both of which regulate mitochondrial biogenesis. This dual action enhances overall energy capacity and cellular resilience. Research suggests that when mitochondrial density and function improve, people often experience greater stamina, reduced fatigue and improved recovery after exertion. That’s why PQQ has become a key ingredient in formulations designed to optimise metabolic health, like our Metabolic Flow. Supporting Cognitive Function Beyond energy metabolism, PQQ has notable effects on brain health. It helps protect neurons from oxidative stress and supports nerve growth factor (NGF) production – a protein essential for neuron development and survival. Studies indicate that PQQ may enhance memory, attention and learning capacity by improving neuronal communication and reducing inflammation within the brain. When combined with other neuro-supportive nutrients such as CoQ10, taurine, riboflavin (B2) and thiamine (B1), PQQ works synergistically to stabilise mitochondrial membranes and sustain steady ATP production in neural tissue. This combination forms the foundation of our Metabolic Flow supplement, developed to support both mental and physical energy without relying on stimulants. PQQ and Inflammation Chronic low-grade inflammation is linked to fatigue, insulin resistance, joint pain and accelerated ageing. Several studies have found that PQQ can modulate inflammatory pathways by reducing levels of CRP, TNF-α and interleukin-6 – key mediators of systemic inflammation. In human trials, participants supplementing with PQQ showed reductions in inflammatory biomarkers and improvements in perceived energy and sleep quality. These findings suggest that PQQ not only enhances mitochondrial efficiency but also helps calm the inflammatory processes that often accompany modern lifestyles. PQQ in Nature PQQ is found naturally in small amounts in certain foods such as kiwifruit, green peppers, parsley, papaya and fermented soy (natto). However, the quantities present in food are minimal – far below the amounts used in clinical studies. The body may also produce trace amounts, but during periods of high oxidative stress or intense metabolic demand, levels can fall short. This is why supplemental PQQ can be particularly beneficial for those under chronic stress, athletes, or individuals seeking better energy metabolism. Our Approach: Metabolic Flow Our Metabolic Flow formula was designed to address the biological systems that govern cellular energy, focus and recovery. Each capsule combines PQQ (5 mg) with CoQ10, taurine, creatine monohydrate, magnesium malate, ginger root and essential B vitamins (B1, B2, B3). This targeted blend supports mitochondrial performance at every stage – from electron transport and ATP synthesis to redox balance and neuroprotection. Unlike synthetic stimulant-based energy products, Metabolic Flow works on the level of mitochondrial optimisation. That means energy is produced naturally and steadily, without spikes or crashes. It’s suitable for those seeking sustained vitality, mental clarity and post-exercise recovery support. Safety and Usage PQQ has demonstrated a strong safety profile in human studies, even at doses significantly higher than those typically used in supplements. Nonetheless, anyone taking medication or managing a medical condition should speak with a healthcare professional before starting a new supplement. Consistency matters most; results are typically observed after several weeks of continuous use as mitochondrial turnover occurs gradually. Key Takeaways PQQ acts as a redox cofactor and powerful antioxidant. It supports mitochondrial biogenesis and improves cellular energy efficiency. PQQ may enhance cognitive function and protect neurons from oxidative stress. Our Metabolic Flow supplement combines PQQ with synergistic nutrients to promote energy, focus and recovery naturally. PQQ’s ability to regenerate mitochondria, reduce inflammation and sustain antioxidant defences makes it one of the most promising compounds for long-term vitality. Our Metabolic Flow formulation captures this science in its purest, most bioavailable form – helping you optimise energy production where it truly begins: inside the cell.

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Supplements That Help Reduce Histamine: Our New Histamine Metabolism Support Complex

by Matt Jarosy

Supplements That Help Reduce Histamine: Our New Histamine Metabolism Support Complex

Histamine is a naturally occurring compound in your body, with a pivotal role in various physiological processes. It's a small molecule that plays a significant role in immune responses, stomach acid production, and neurotransmission. While histamine is essential for several bodily functions, an excess of it can lead to a range of uncomfortable symptoms. In this article, we will explore what histamine is, the symptoms of excess histamine, common triggers, and the enzymes responsible for metabolizing histamine. What Is Histamine? Histamine, chemically known as 2-(4-imidazolyl)ethylamine, is a neurotransmitter and a biogenic amine. It is synthesized from the amino acid histidine through a series of enzymatic reactions. Once produced, histamine is stored in specialized cells called mast cells and basophils, primarily in tissues that are in direct contact with the external environment, such as the skin, respiratory tract, and gastrointestinal tract. Symptoms of Excess Histamine Histamine plays a vital role in your immune system, helping to defend your body against pathogens. However, excessive histamine levels can lead to a range of unpleasant symptoms. This condition is known as histamine intolerance, and its symptoms can mimic allergies or other health issues. Common symptoms of excess histamine include Skin Issues: Itching, hives, redness, and eczema are frequent skin reactions to excess histamine. Histamine can cause blood vessels to dilate, leading to these visible skin changes Gastrointestinal Problems: Excess histamine can affect your stomach and intestines, causing symptoms like abdominal pain, bloating, diarrhea, and nausea. Respiratory Symptoms: Histamine can constrict airways and trigger symptoms like sneezing, congestion, and wheezing, which are often associated with allergies Headaches and Migraines: Histamine is a potent vasodilator, meaning it can expand blood vessels in the brain and lead to headaches or migraines. Cardiovascular Symptoms: Some people may experience low blood pressure and an increased heart rate due to histamine-induced blood vessel dilation Fatigue: Histamine intolerance can also lead to fatigue and a general feeling of malaise. Common Triggers of Histamine: Understanding what triggers excess histamine is crucial for managing histamine intolerance. Several factors can contribute to elevated histamine levels in the body. Diet: Certain foods are high in histamine or trigger its release. These include aged cheeses, fermented foods, alcohol, and processed or smoked meats Allergies: Allergic reactions can release large amounts of histamine in response to allergens like pollen, dust mites, or pet dander. Gut Health: An imbalance of gut bacteria can impair the breakdown of histamine in the digestive tract, leading to its accumulation Medications: Some medications, such as non-steroidal anti-inflammatory drugs (NSAIDs) and certain antacids, can interfere with histamine metabolism Stress: Stress can stimulate the release of histamine, exacerbating symptoms in individuals with histamine intolerance. Enzymes that Metabolize Histamine: In your body, histamine levels are carefully regulated by enzymes that break it down and convert it into inactive metabolites. Two key enzymes involved in histamine metabolism are: Diamine Oxidase (DAO): This enzyme is primarily responsible for breaking down histamine in the digestive tract. It's produced by the cells lining your gut and helps prevent histamine from being absorbed into the bloodstream. Histamine N-Methyltransferase (HNMT): HNMT is found in various tissues throughout the body and plays a role in metabolizing histamine in the brain and other organs. It helps regulate histamine levels in the central nervous system. When these enzymes are functioning correctly, they help maintain a balance of histamine in your body. However, genetic factors, medications, or gut health issues can impair the activity of these enzymes, contributing to histamine intolerance. Our new histamine complex uses a variety of ingredients to not only reduce the effects of histamine but also help your body metabolise it more efficiently. Including: Creatine Monohydrate - Enhancing Histamine Metabolism and Energy ProductionCreatine monohydrate indirectly promotes histamine metabolism by supporting the activity of histamine-metabolizing enzymes, such as diamine oxidase (DAO) and histamine-N-methyltransferase (HNMT). By facilitating the breakdown of histamine, creatine reduces its accumulation and helps alleviate histamine intolerance symptoms. Additionally, creatine plays a vital role in cellular energy production, ensuring optimal function and efficiency in histamine metabolism.Organic Acerola: Natural Vitamin C - Antioxidant Defense and Histamine ModulationAcerola is a rich source of natural vitamin C which is a potent antioxidant. Vitamin C protects against histamine-induced oxidative stress, which can exacerbate histamine intolerance symptoms. By neutralizing free radicals and reducing oxidative damage, vitamin C helps maintain a balanced histamine response. Furthermore, vitamin C exhibits anti-inflammatory properties and supports immune function, contributing to a well-regulated histamine system.L-Theanine - Calming Inflammation and Modulating Histamine ReleaseL-theanine, derived from green tea, exerts anti-inflammatory effects by inhibiting the activation of pro-inflammatory signaling molecules, such as nuclear factor-kappa B (NF-κB). By reducing inflammation, L-theanine helps modulate histamine release and mitigate histamine-related discomfort. Moreover, L-theanine promotes relaxation by enhancing alpha brain wave activity, which can reduce stress-induced histamine release. Bromelain - Digestive Support and Histamine BreakdownBromelain, a proteolytic enzyme found in pineapple, aids in the digestion of proteins, including histamine-rich foods. By facilitating protein breakdown, bromelain supports proper digestion and minimizes the absorption of intact histamine molecules. This digestive support helps reduce histamine accumulation in the body and alleviates digestive symptoms associated with histamine intolerance. Bromelain has also been shown to inhibit the production of pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). By reducing inflammation, bromelain may indirectly decrease the release or synthesis of histamine in certain immune cells.Boswellia - Anti-inflammatory Action and Histamine BalanceBoswellia possesses potent anti-inflammatory properties due to its active components, such as boswellic acids. By inhibiting the activity of pro-inflammatory enzymes, including 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2), boswellia helps reduce histamine-induced inflammation and promotes a balanced histamine response. This anti-inflammatory action contributes to overall histamine tolerance and alleviation of associated symptoms.Copper - The Central Atom of Histamine Metabolism EnzymesMinerals play an important role in histamine balance and copper is no exception. Copper is an essential cofactor for DAO, the primary enzyme responsible for breaking down histamine in the gut. Adequate copper levels ensure proper DAO activity, facilitating efficient histamine metabolism and preventing its accumulation.Vitamin B6 - Enzyme Co-Factor in Histamine ClearanceVitamin B6, also known as pyridoxine or P5P, plays a crucial role in the metabolism of histamine. It is a cofactor in the production of enzymes that metabolise histamine, further supporting its regulation. While vitamin B6 may not directly lower histamine levels, its role in histamine metabolism suggests that it can help alleviate the effects of histamine-related conditions, such as allergies or histamine intolerance. Bifidobacterium infantis and Bifidobacterium longum - Gut Microbiota Support for Improved Histamine ToleranceBifidobacterium infantis and Bifidobacterium longum, two beneficial probiotic strains, play a crucial role in supporting a healthy gut microbiota. By promoting a balanced microbial environment, these strains help optimize digestion and reduce histamine production in the gut. Furthermore these two specific strains have been to suppress allergic type symptoms and decrease histamine levels. Find out more here

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Unveiling the Power of Coenzyme Q10 (CoQ10): A Comprehensive Guide

by Matt Jarosy

Unveiling the Power of Coenzyme Q10 (CoQ10): A Comprehensive Guide

In the realm of health and wellness, the spotlight often falls on various vitamins and minerals, but one lesser-known yet crucial compound deserves attention – Coenzyme Q10, also known as ubiquinone (because of its ubiquitous presence in organisms). It's chemical name is 2,3-dimethoxy-5-methyl-6-multiprenyl-1,4-benzoquinone (did you try to pronounce that? We hope so). This naturally occurring antioxidant is present in every cell of the human body, playing a vital role in energy production, antioxidant defense, and overall cellular health. Forms of CoQ10 SupplementsSupplemental CoQ10 comes in various forms however the two primary forms available in the market are ubiquinone and ubiquinol.Ubiquinone: This is the oxidized form of CoQ10 and is the more stable of the two and one we use in our formulations. Once ingested, the body converts ubiquinone into ubiquinol, the active antioxidant form. It has demonstrated efficacy in supporting overall health.Ubiquinol: This is the reduced, active form of CoQ10. Ubiquinol is absorbed by the body without the need for conversion but is less stable. This is why we prefer to allow the body to perform the process of oxidation by using ubiquinone. Functions in the Human Body COQ10 it’s not like your everyday mitochondria worker and that's because it's the only component that is not anchored to the inner mitochondrial membrane allowing a certain degree of freedom. It’s also very stable making it a tough antioxidant too (similar structure to vitamin E). It can handle some unstable molecules and rustle them into place with ease. The areas in the body with the highest energy requirements have the highest CoQ10 which makes sense given its role, so for example, the heart and liver.Energy Production: One of the primary functions of CoQ10 is its involvement in the electron transport chain, a critical step in cellular respiration. This process takes place in the mitochondria, where CoQ10 facilitates the production of adenosine triphosphate (ATP), the energy currency of the cell.Cellular Health: CoQ10 plays a crucial role in maintaining the structural integrity of cell membranes, supporting overall cellular health and function. CoQ10 is transported in the bloodstream attached to VLDL and LDL cholesterol, with a plasma half-life of about 30 hours. CoQ10 is very efficient at inhibiting lipid peroxidation in LDL cholesterol.Dietary Sources of CoQ10While CoQ10 is naturally synthesized in the body, it can also be obtained through dietary sources. Foods rich in CoQ10 include:Fish: Salmon, mackerel, and sardines are excellent sources of CoQ10, providing not only this essential compound but also trace minerals.Meat: Organ meats such as liver and kidney contain high concentrations of CoQ10, making them valuable dietary sources.Whole Grains: Whole grains like wheat germ and whole wheat bread contain CoQ10, contributing to its intake through a balanced diet.Fruits and Vegetables: While the levels are lower compared to animal products, fruits like oranges and strawberries, as well as vegetables like broccoli and cauliflower, contribute to overall CoQ10 intake.Benefits of CoQ10 SupplementationCardiovascular Health: CoQ10 is often touted for its cardiovascular benefits. Studies suggest that supplementation may help lower blood pressure, reduce oxidative stress, and improve overall heart function.Anti-Aging Properties: As we age, the body's natural production of CoQ10 declines. Supplementing with CoQ10 has been linked to improved skin health, including reduced wrinkles and enhanced skin hydration.Mitochondrial Support: CoQ10's pivotal role in energy production makes it essential for mitochondrial health. Supplementation may aid in addressing conditions related to mitochondrial dysfunction, promoting overall energy and vitality.Cognitive Function: Some research suggests that CoQ10 supplementation may have neuroprotective effects, potentially slowing cognitive decline and supporting brain health.Exercise Performance: Athletes and fitness enthusiasts often turn to CoQ10 supplements to enhance endurance and reduce exercise-induced muscle damage, though more research is needed in this area. Fertility: COQ10 plays an important role in egg development and sperm health making it a top choice for those wanting to conceive. Why We Need More as We AgeAs we age, the body's ability to produce and utilize CoQ10 diminishes. This decline is particularly pronounced after the age of 30. Several factors contribute to this reduction, including lifestyle factors, medication use, and the natural aging process itself.Medication Interactions: Some medications, such as statins used to lower cholesterol, can deplete CoQ10 levels in the body. Supplementing with CoQ10 is often recommended for individuals on such medications to counteract this depletion.Increased Oxidative Stress: Aging is associated with an increase in oxidative stress, leading to higher levels of free radicals. CoQ10, as a potent antioxidant, becomes even more crucial in neutralizing these free radicals and protecting cells from damage.Decline in Mitochondrial Function: Mitochondrial dysfunction is a hallmark of aging. CoQ10's role in the mitochondria becomes increasingly vital to support cellular energy production and overall cellular health.ConclusionCoenzyme Q10, with its diverse functions and numerous benefits, emerges as a vital player in the maintenance of optimal health. Whether obtained through dietary sources or supplementation, CoQ10 is an invaluable compound that supports cardiovascular health, mitigates the effects of aging, and enhances overall well-being. As our bodies age and face increasing challenges, ensuring an adequate supply of CoQ10 becomes a proactive step towards promoting longevity and vitality. Embracing the power of CoQ10 may be a key to unlocking the secrets of aging gracefully and maintaining robust health throughout the journey of life. Our mitochondrial support complex contains 100mg of COQ10 along with a similar compound known as PQQ. References Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.  Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression.Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial. Atherosclerosis. Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials.

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