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by Matt Jarosy

Everything You Need To Know On Magnesium Glycinate

Magnesium glycinate (or bisglycinate) is a highly bioavailable form of magnesium made by chelating magnesium to the amino acid glycine. Chelated magnesium is a unique preparation method that offers increased stability, better bioavailability, and less chance of impacting the digestive tract. Magnesium glycinate is thought to be one of the most relaxing forms of magnesium, partly because of what it is chelated to, in this case glycine. Glycine (also known as 2-Aminoacetic Acid) is an amino acid and a neurotransmitter. It has a broad range of roles in the body, from regulating blood sugar to faciliating the production DNA and RNA. It is also one of three amino acids that your body uses to make glutathione, a powerful antioxidant that helps protect your cells against oxidative damage caused by free radicals. Although glycine can be both excitatory and inhibitory, many people find it relaxing on the nervous system. Studies show that higher levels of this amino acid may, help you fall asleep more quickly, reduce symptoms of insomnia and promote deeper more restful sleep. Which magnesium to use We recommend people try different forms of magnesium to see which form they prefer. Some of our customers like to take magnesium malate in the morning and magnesium glycinate in the evening. It's important to listen to your body and find the form and dose that works for you.

by Matt Jarosy

Fueling Your Mitochondria: Make More Energy

Mitochondria are membranous, slightly elongated structures contained within the cytoplasm of almost all eukaryotic cells. Using aerobic respiration, they take oxygen and the compounds in our food to make energy (in the form adenosine triphosphate, known as 'ATP'). Each cell contains the appropriate amount of mitochondria relative to its energy use. That means organs such as the heart contain a lot of mitchondria, infact each cell of your heart contains around 5000 mitochondria. When we lose mitochondria or they begin to malfunction, it can increase our risk of 'dis-ease'. It is thought that mitochondria were originally independent bacterial entities which at some point over a billion years ago (through much trial and error) entered other bacterial cells and decided to partner up. This moment was monumentous, you could argue this was the beginning of complex life as we know it. Two important cycles that occur within the mitochondria for energy production are the the tricarboxylic acid cycle (TCA) and the electron transport chain (ECT). Think of these like factory lines, they need to be flowing freely in order for energy to be generated efficiently. During normal oxidative phosphrlation (whereby ATP is formed by electron transfer) about 2 percent of the oxygen consumed is converted to superoxide (a type of free radical). This is where nutrition comes, anti-oxidants from our diet help to mop up the free radicals formed by energy production. Unfortunately, making energy comes with exhaust. So what do mitochondria need to function properly? Magnesium: In order for ATP be 'activated', it needs to form a complex with magnesium. B Vitamins: These are like the workers on the factory line, helping to pass energy from one cycle to another. Each B vitamin has a specific role, for example riboflavin (B2) plays a key role in shuttling electrons from the TCA and cobalamin (B12) is needed to generate s-adenosyl methionine (SAMe) which is part of the protein sub unit that makes up the ECT. COQ10: You can think of COQ10 as the oil in the factory, it helps to keep things running smoothly. It can regenerate free radicals and soothe them back into the ECT. PQQ: Otherwise known as pyrroloquinoline quinone, helps control redox processes in the mitochondrial, essentially balancing oxidative stress as well as stimulating energy production. B3: We need B3 or niacinamide to manufacture NADH (energy carrier) and to supply protons for oxidative phosphorylation. Copper: Copper is a cofactor in the ECT so that ATP can be released, it also plays a key role in mitochondrial signaling and mitophagy. Given mitochondria's role in the body, mitocondrial may be the key to unlocking the process of aging itself. According to this theory, with age, mitochondria accumulate ROS-induced damage and become dysfunctional. With time, the function of cells declines causing aging and subsequent death. Many things can induce oxidative stress in humans, including not having the necessary cofactors for making energy. Remember, making energy makes exhuast. The more we can buffer this exhaust, the better.

by Matt Jarosy

Pyrroloquinoline quinone: From Stardust to Mitochondria

We've recently launched our mitochondrial support supplement which contains a compound known as Pyrroloquinoline quinone, otherwise known as PQQ. In this post we wanted to dive into what this compound is and its functions. PQQ is a small molecule that is found in plants, bacteria, and some animal tissues. It has a chemical structure similar to that of vitamins and is classified as a redox cofactor, which means that it can participate in chemical reactions that involve the transfer of electrons. PQQ has gained attention in recent years due to its potential health benefits, including its ability to act as an antioxidant and support cognitive function. Recent evidence suggests that compounds like PQQ are components of interstellar dust, considered precursors to organic life. One of the primary functions of PQQ is its ability to act as an antioxidant. Antioxidants are substances that can neutralize harmful molecules called free radicals, which can cause damage to cells and contribute to the development of diseases such as cancer and heart disease. PQQ has been shown to be a potent antioxidant, with the ability to scavenge free radicals and prevent their damaging effects. It has also been shown to stimulate the production of other antioxidants in the body, including superoxide dismutase (SOD) and glutathione. PQQ has also been shown to modulate the expression of certain genes that are involved in energy metabolism and mitochondrial function. In particular, PQQ has been shown to increase the expression of genes that are involved in the production of mitochondria and the transport of proteins into mitochondria, which may help to improve their function. PQQ has also been studied for its potential cognitive benefits. Some research has suggested that PQQ may support cognitive function by protecting neurons, or brain cells, from oxidative stress. It has also been shown to promote the growth and survival of neurons, which may help to improve brain function.In addition to its potential cognitive benefits, PQQ has also been studied for its effects on energy metabolism and mitochondrial function. Mitochondria are the powerhouses of cells, responsible for producing the energy from oxidative phosphorylation that cells need to function. PQQ has been shown to improve the function of mitochondria and increase the production of energy in cells. This may have a variety of potential health benefits, including improving physical performance and reducing fatigue. There is also some evidence to suggest that PQQ may have anti-inflammatory effects. Inflammation is a normal response to injury or infection, but chronic inflammation has been linked to a number of diseases, including heart disease, diabetes, and cancer. PQQ has been shown to reduce inflammation in animal studies, and there is some evidence to suggest that it may have similar effects in humans. PQQ is found naturally in small amounts in a variety of foods, including kiwifruit and peppers. Although the body can produce small amounts of PQQ, more may be needed in times of oxidative stress. In this situation additional PQQ may be able to help balance redox status so that we can make energy efficiently. The available evidence suggests that PQQ may have a variety of potential benefits for human health, including its ability to act as an antioxidant, support cognitive function, improve energy metabolism and mitochondrial function, and reduce inflammation. As with any supplement, it is important to speak with a healthcare provider before starting to use PQQ, especially if you have any existing health conditions or are taking any medications. References Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects

by Matt Jarosy

The Power of Vitamin C in Human Health

With the launch of our latest organic wholefood vitamin C formulation, we wanted a dive a bit more into the benefits of wholefood vitamin C and why it should be a regular part of your diet. Vitamin C is one of the most well-known and widely studied vitamins out there. It was first discovered in the 18th century and since then, we've learned a lot about its many functions in the body. It's been shown to help support a healthy immune system, skin health, and even cognitive function. Here's a list of all specific functions of vitamin C Required for synthesis of collagen fibers through hydroxylation of proline and lysine. Nourishes the adrenal glands by supporting healthy steroid hormone production. Enhances chemotaxis, phagocytosis, and ultimately microbial killing as part of the immune response. Enhances differentiation and proliferation of B and T-cells, important immune regulatory cells. Activation of the B vitamin folic acid and the conversion of cholesterol to bile acids which are needed for digestion. Conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. Helps balance LDL & HDL cholesterol. But what many people don't know is that not all vitamin C is created equal. Whilest you can find synthetic vitamin C in many supplements derived from processed corn, wholefood vitamin C contain all of the nutrients and fiber that nature intended. So why choose wholefood vitamin C? Wholefoods tend to be more bioavailable than synthetic nutrients. This means that your body can more easily absorb and use the nutrient. Additionally, wholefood vitamin C contains other important nutrients like flavonoids and phytochemicals that work together to provide even more health benefits. It also contains tyrosinase, a copper containing enzyme used in melanin which gives our skin its color. So why do regular vitamin C supplements have such high dosages? This is due to the fact that these vitamins are not bound to other nutrients and fiber like they are in wholefoods. It's important to note that just because there's a higher dosage, it doesn't mean you will absorb it all. In fact, most people only absorb about 20-30% of the synthetic vitamin C they take in supplement form. When you take wholefood vitamin C, your body is able to utilise all the components as nature intended. If you're looking for a way to increase your intake of vitamin C, our new organic wholefood vitamin C supplement is a great option. It's made with freeze dried acerola cherries, camu camu berries & peppermint- all of which are rich sources of vitamin C. Plus, it's certified organic, non-GMO, and vegan. Organic certification means that the ingredients are grown without the use of synthetic pesticides, herbicides, or fertilizers. Non-GMO means that the ingredients have not been genetically modified in any way. Now you might be wondering why peppermint? For some people, wholefood vitamin C can cause a histamine reaction (even though vitamin C is a natural antihistamine) so we added a pinch of peppermint to our formulation to help reduce the histamine load. Peppermint also has other benefits like supporting digestion and providing a boost of energy. Whats the best way to take vitamin C? If it's your first time trying this supplement, we would always suggest trying 1 capsule after food first. This allows your body time to get used to the supplement and helps reduce any potential digestive discomfort. Once you have tried it this way feel free to increase the dosage to 3 capsules or as professionally directed. We like to take our wholefood vitamin C away from food for optimum absorption. References https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6098779/?ref=E_pvv9KrdcFc94 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296744/?ref=E_pvv9KrdcFc94 https://pubmed.ncbi.nlm.nih.gov/29763052/

by Matt Jarosy

Which Form of Magnesium Should I Take? Magnesium Bisglycinate, Magnesium Taurate & Magnesium Malate

Magnesium is an essential mineral that plays a crucial role in many biological processes, including energy production, protein synthesis, and nerve function. However, many people do not get enough magnesium in their diets, and as a result, magnesium deficiency is a common problem worldwide; some estimates suggest that up to 50% of the population may not be getting enough magnesium in their diets. Fortunately, magnesium supplements can help to fill the gaps but with so many different forms of magnesium it can be difficult to know which one to choose. In this article, we will discuss the differences between our three popular forms of magnesium supplements: magnesium malate, taurate, and glycinate. First, let's talk about what a magnesium chelate is. A chelate is a molecule that binds to a metal ion, in this case, magnesium, to form a stable complex. Chelated magnesium supplements are designed to enhance absorption and bioavailability, meaning the body can more easily absorb and utilize the magnesium. There are many different types of magnesium chelates, but malate, taurate, and glycinate are among the most popular.Magnesium malate is a chelated form of magnesium that is bound to malic acid. Malic acid is a natural compound found in many fruits and vegetables, and it plays a role in the production of energy in the body. Magnesium malate is often used to help support energy production, as well as to promote muscle relaxation and reduce muscle pain and stiffness. It is also thought to be beneficial for people with fibromyalgia, a condition characterized by widespread muscle pain and fatigue. Magnesium malate is generally well-tolerated and does not usually cause digestive upset.Magnesium taurate is a chelated form of magnesium that is bound to taurine, an amino acid that is found in many foods, including meat and fish. Taurine is known for its ability to support cardiovascular health and improve exercise performance, and it may also help regulate blood sugar levels. Magnesium taurate is often used to help support healthy heart function and improve exercise endurance. It is also thought to be helpful for people with anxiety or depression, as taurine has been shown to have calming and mood-stabilizing effects. Magnesium taurate is generally well-tolerated and does not usually cause digestive upset.Magnesium glycinate is a chelated form of magnesium that is bound to glycine, an amino acid that is found in many high-protein foods, including meat, fish, and dairy. Glycine is known for its ability to promote relaxation and improve sleep quality, and it may also help support healthy brain function. Magnesium glycinate is often used to help support healthy sleep patterns and reduce symptoms of anxiety and stress. It is also thought to be beneficial for people with digestive issues, as glycine has been shown to help repair the lining of the digestive tract. Magnesium glycinate is generally well-tolerated and does not usually cause digestive upset.So, which form of magnesium is best for you? The answer depends on your individual needs and health goals. If you are looking to support energy production and reduce muscle pain and stiffness, magnesium malate may be the best choice for you. If you are looking to support cardiovascular health and improve exercise performance, magnesium taurate may be the best choice for you. If you are looking to promote relaxation, improve sleep quality, and reduce symptoms of anxiety and stress, magnesium glycinate may be the best choice for you. However, it is important to note that all three forms of magnesium have some degree of overlap in their benefits, and any of them may be helpful for general magnesium supplementation.It is important to note that while magnesium supplements are generally safe and well-tolerated, taking too much magnesium can cause digestive upset. Therefore, it is important to follow the recommended dosage guidelines on the supplement label and to consult with a healthcare provider before starting any new supplement regimen.Finally, let's briefly discuss some symptoms of magnesium deficiency. Magnesium deficiency is a common problem, and it can cause a wide range of symptoms, including muscle cramps, fatigue, irritability, anxiety, and irregular heartbeat. In more severe cases, magnesium deficiency can lead to conditions such as osteoporosis, hypertension, and diabetes.In conclusion, magnesium is an essential mineral that plays a critical role in many biological processes, and magnesium supplements can be a helpful way to ensure that you are getting enough magnesium in your diet. Choosing the right form of magnesium for you depends on your individual needs and health goals. You can find out full range of magnesium blends here. References Magnesium in Prevention and Therapy - https://pubmed.ncbi.nlm.nih.gov/26404370/. The Role of Magnesium in Neurological - Disorders: https://pubmed.ncbi.nlm.nih.gov/31284519/ Magnesium and Depression: A Systematic Review - https://pubmed.ncbi.nlm.nih.gov/29996882/ Magnesium in Hypertension, Cardiovascular Disease, Metabolic Syndrome, and Other Conditions: A Review - https://pubmed.ncbi.nlm.nih.gov/31594303/ Magnesium and Sleep: A Systematic Review of Human Trials - https://pubmed.ncbi.nlm.nih.gov/28675917/

by Matt Jarosy

Why Choose Organic Ingredients?

All our wholefood range is certified organic by the Soil Association. The Soil Association symbol is a recognised and trusted mark of organic certification internationally but why choose organic? Rather than relying on chemical inputs, organic farmers and growers adopt management practices that build and enhance natural soil fertility with the application of organic matter, green manures and long-term crop rotations, and controlling weeds, pests and diseases through mechanical weeding, variety choice and by encouraging natural predators. A growing number of studies are now linking pesticides to various human health effects. A 2004 review co-authored by the National Cancer Institute concluded that “epidemiological evidence clearly suggests that at current exposures pesticides adversely affect human health”. Some pesticides are also known to disrupt endocrine or hormone function, research reviewed by the EPA and published in a toxicology handbook states. A 2013 report commissioned by the European Food Safety Authority reviewed 600 research studies on pesticides and found the strongest associations with certain cancers, asthma, childhood leukemia and Parkinson’s disease. But it's not just human health, organic farms have up to 50% more wildlife abundance on average. By supporting organic farming practices, you help support both the environment and your health. You can find our certified organic range here. References https://www.soilassociation.org/take-action/organic-living/why-organic/better-for-wildlife/ https://www.annualreviews.org/doi/full/10.1146/annurev.publhealth.25.101802.123020#_i34 https://efsa.onlinelibrary.wiley.com/doi/10.2903/j.efsa.2017.5007